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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Nicotine abstinence syndrome precipitated by the competitive nicotinic antagonist dihydro-beta-erythroidine.
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Nicotine abstinence syndrome precipitated by the competitive nicotinic antagonist dihydro-beta-erythroidine.

机译：竞争性烟碱类拮抗剂二氢-β-类胡萝卜素引发了尼古丁戒断综合征。

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摘要

Rats infused subcutaneously with 9 mg/kg/day nicotine tartrate for 7 days exhibit behavioral abstinence signs following either termination of nicotine infusion or injection of the noncompetitive nicotinic antagonists mecamylamine (s.c.) or hexamethonium (ic.c.v.). This study examined the abstinence precipitating effects of dihydro-beta-erythroidine (DHbetaE), a competitive nicotinic antagonist. Twenty-four nicotine-dependent rats were injected in the third ventricle with 10, 18, or 25 microg DHbetaE in 20 microl saline or with saline alone and observed for abstinence signs over a 20-min period. There was a significant positive linear trend of overall abstinence signs as a function of dose, p < 0.01. In 12 nondependent rats, the high dose of DHbetaE did not induce more abstinence-like signs than saline alone. In a second experiment, 18 nicotine-dependent rats were injected s.c. with 1 or 6 mg/kg of the muscarinic antagonist scopolamine or with saline alone. Few abstinence signs were observed in any group: there was no significant drug effect. The results suggest that nicotine abstinence signs observed in the rat are specific to reduced stimulation of previously overstimulated nicotinic receptors.
机译：皮下注射9 mg / kg /天的酒石酸烟碱尼古丁7天的大鼠在停止烟碱注射或注射非竞争性烟碱拮抗剂美卡敏（s.c.）或六甲铵（ic.c.v.）后表现出行为禁欲迹象。这项研究检查了竞争性烟碱拮抗剂二氢-β-类胡萝卜素（DHbetaE）的戒断沉淀作用。在第三脑室中向24只尼古丁依赖性大鼠注射在20微升盐水中或单独用盐水的10、18或25微克DHbetaE，或在20分钟内观察戒断症状。总体禁欲迹象与剂量呈显着正线性关系，p <0.01。在12只非依赖性大鼠中，高剂量的DHbetaE没有比单独的盐水诱导更多的禁欲样体征。在第二个实验中，皮下注射18只尼古丁依赖性大鼠。用1或6 mg / kg毒蕈碱拮抗剂东pol碱或单独用盐水。在任何一组中都没有观察到戒酒的迹象：没有明显的药物作用。结果表明，在大鼠中观察到的尼古丁戒断症状对先前过度刺激的烟碱样受体的刺激减少具有特异性。

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