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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The effects of MK-801 on spatial working memory and within-session spatial learning.
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The effects of MK-801 on spatial working memory and within-session spatial learning.

机译：MK-801对空间工作记忆和会话内空间学习的影响。

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摘要

The present study investigated the effects of the NMDA channel blocker MK-801 (0.05, 0.10, and 0.15 mg/kg) on a task that allows for the assessment of both spatial working memory and within-session spatial learning. During the first trial of each day, subjects were shown the spatial location of a food reward on a six-arm radial-arm maze. During nine subsequent free-choice trials, subjects were reinforced for returning to that same spatial location. The location of the food reward varied across days. Thus, choosing correctly on any given trial required subjects to remember where food had been received during the previous trials of that day. The effects of MK-801 on working memory were assessed by analyzing the overall number of errors committed during the nine free-choice trials of each day. The effects of MK-801 on within-session learning were assessed by comparing the number of errors committed during the first three trials of each day to the number of errors committed during the last three trials of each day. Only the highest dose of MK-801 tested (0.15 mg/kg) impaired spatial working memory. No dose of MK-801 impaired the ability of subjects to acquire spatial information within a given session. The failure of MK-801 to impair within-session spatial learning stands in contrast to the well-known effects of MK-801 on spatial learning measured across days. Thus, when coupled with previous research, the findings of the present study further suggest that the NMDA receptor plays a role in the long-term, but not short-term, storage of spatial information.
机译：本研究调查了NMDA通道阻滞剂MK-801（0.05、0.10和0.15 mg / kg）对一项任务的影响，该任务允许评估空间工作记忆和会话内空间学习。在每天的第一次试验中，向受试者显示六臂radial臂迷宫中食物奖励的空间位置。在随后的九次自由选择试验中，受试者被加强以返回相同的空间位置。奖励食物的位置随天而变。因此，在任何给定的试验中正确选择都要求受试者记住当天的先前试验中从何处获得食物。通过分析每天进行的九次自由选择试验中犯下的错误总数，来评估MK-801对工作记忆的影响。通过将每天前三项试验中犯下的错误数与每天后三项试验中犯下的错误数进行比较，来评估MK-801对会话内学习的影响。仅测试的最高剂量的MK-801（0.15 mg / kg）损害了空间工作记忆。没有剂量的MK-801会损害对象在给定会话中获取空间信息的能力。 MK-801无法削弱会话内空间学习的原因与MK-801对跨天进行的空间学习的众所周知的影响形成鲜明对比。因此，当与先前的研究相结合时，本研究的发现进一步表明，NMDA受体在空间信息的长期而非短期存储中起作用。

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