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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Rimonabant abolishes sensitivity to workload changes in a progressive ratio procedure
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Rimonabant abolishes sensitivity to workload changes in a progressive ratio procedure

机译：利莫那班取消了累进比率法对工作量变化的敏感性

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Despite its propensity to increase motivation for food consumption, marijuana use in humans has been associated with "amotivational syndrome." This "amotivational syndrome" can be characterized by a reduction in response persistence in tasks requiring sustained, but not maximal, effort. To examine this hypothesis, dose-effect functions for THC (0.03-10 mg/kg) and rimonabant (0.1-10 mg/kg) were first determined under a time-constrained PR 5 schedule. During the second phase of the study, doses of THC and rimonabant that did not affect the responses/total reinforced responses were chosen for further evaluation in a series of PR schedules with step sizes of PR 3, PR 5, PR 10, and PR exponential. THC and rimonabant produced decreases in responses per reinforcer, and response rate when behavior was maintained on a PR 5. Rimonabant also decreased session length. During the PR step size manipulation phase, rimonabant decreased responses/total reinforced responses, response rate, and session length, whereas THC only decreased response rate. These results are consistent with previous literature demonstrating that rimonabant decreases motivation for food both in cases where it is earned, as well as under free-feeding conditions, whereas the effects of cannabinoid agonists such as THC on responding for food exhibit greater dependence upon motivational and non-motivational factors, including workload and duration of the task.
机译：尽管大麻有增加食物消费动机的趋势，但在人类中使用大麻却与“动机综合症”有关。这种“自动驾驶综合症”的特征在于减少了需要持续但并非最大努力的任务的反应持久性。为了检验这一假设，首先根据时间受限的PR 5时间表确定THC（0.03-10 mg / kg）和利莫那班（0.1-10 mg / kg）的剂量效应功能。在研究的第二阶段，选择不影响反应/总增强反应的四氢大麻酚和利莫那班剂量，以一系列PR时间表进一步评估，步长分别为PR 3，PR 5，PR 10和PR指数。 。当在PR 5上维持行为时，THC和利莫那班产生的每个补强药反应降低，并且反应速率降低。利莫那班也减少了疗程。在PR步长控制阶段，利莫那班降低了应答/总强化应答，应答率和疗程长度，而THC仅降低了应答率。这些结果与以前的文献一致，表明利莫那班在赚钱的情况下以及在自由进食条件下均会降低食物的动力，而大麻素激动剂（如THC）对食物反应的影响则显示出对动力和动力的更大依赖性。非激励因素，包括工作量和任务持续时间。

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