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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Aleurites moluccana and its main active ingredient, the flavonoid 2″-O-rhamnosylswertisin, have promising antinociceptive effects in experimental models of hypersensitivity in mice
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Aleurites moluccana and its main active ingredient, the flavonoid 2″-O-rhamnosylswertisin, have promising antinociceptive effects in experimental models of hypersensitivity in mice

机译：Aleurites moluccana及其主要活性成分类黄酮2″ -O-鼠李糖基维他命在小鼠超敏反应实验模型中具有有希望的抗伤害作用

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This study investigated the antinociceptive effect of Aleurites moluccana dried extract (DE; 125 to 500 mg/kg, p.o.) and the isolated flavonoid 2″-O-rhamnosylswertisin (5 to 50.6 μmol/kg, p.o.) using different models of long-lasting inflammatory and neuropathic pain in mice. Attempts were made to analyse the mechanisms through which A. moluccana exerted its effects. A. moluccana DE inhibited complete Freund's adjuvant (CFA)-induced mechanical nociception. It was also evidenced by a reduction of sensitization in the contralateral hindpaw. The extract reversed the mechanical hypersensitivity of partial ligation of sciatic nerve (PLSN)-treated animals, similar to gabapentin. In PLSN model, the opioid, dopaminergic and oxidonitrergic pathways were involved in the A. moluccana DE antinociceptive effects. A single dose of 2″-O-rhamnosylswertisin inhibited the carrageenan- and CFA-induced mechanical nociception. Furthermore, the compound caused expressive antinociception in PLSN-mice, with inhibition value greater than obtained with gabapentin. Oral treatment with the extract or the isolated compound attenuated the neutrophil migration and IL-1β levels following carrageenan injection. Of note, A. moluccana DE did not interfere with thermal sensitivity in healthy mice. The absence of side effects, including interference in locomotor activity, motor performance in animals treated with the extract, showed excellent potential for the therapeutic use of this medicinal plant in treating persistent pain in humans.
机译：这项研究使用不同的持久模型，研究了Aleurites moluccana干燥提取物（DE; 125至500 mg / kg，口服）和分离的类黄酮2″ -O-鼠李糖脂蛋白（5至50.6μmol/ kg，口服）的镇痛作用。小鼠炎症性和神经性疼痛。试图分析A. moluccana发挥其作用的机制。 A. moluccana DE抑制完全弗氏佐剂（CFA）诱导的机械伤害感受。对侧后爪的致敏性降低也证明了这一点。该提取物逆转了坐骨神经（PLSN）处理动物的部分结扎的机械性超敏反应，类似于加巴喷丁。在PLSN模型中，阿片，多巴胺能和氧化神经能通路参与了A. moluccana DE的镇痛作用。单一剂量的2” -O-鼠李糖苷酶抑制角叉菜胶和CFA诱导的机械伤害感受。此外，该化合物在PLSN小鼠中引起表达性抗伤害作用，其抑制值大于加巴喷丁获得的抑制作用。角叉菜胶注射后，用提取物或分离的化合物口服处理可减轻中性粒细胞迁移和IL-1β水平。值得注意的是，A。moluccana DE不会干扰健康小鼠的热敏感性。在没有副作用的情况下，包括对运动活性的干扰，用提取物治疗的动物的运动表现，均显示出这种药用植物在治疗人类持续性疼痛方面的治疗潜力。

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