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Alcohol pharmacokinetics and risk-taking behaviour following exercise-induced dehydration

机译：运动性脱水后的酒精药代动力学和冒险行为

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This study investigated the influence of exercise-induced dehydration on alcohol pharmacokinetics, subjective ratings of impairment, and risk-taking behaviours. Twelve male volunteers participated in 3 experimental trials completed in a randomised cross over design separated by at least 7 days. In one trial, participants exercised to cause dehydration of ~ 2.5% body weight loss. For the other trials, participants were required to be in a rested and euhydrated state. A set volume of alcohol was then consumed in each trial and participants were monitored over a 4 h period. Blood (BAC) and breath (BrAC) alcohol samples were collected throughout and analysed to calculate pharmacokinetic variables associated with the blood alcohol curve. Total urine production, estimates of BrAC, and subjective ratings of intoxication and impairment were also recorded throughout each trial. No difference was found in the pharmacokinetics of alcohol between any of the trial conditions. BrACs were higher than BACs for 2 h following alcohol consumption, but lower at measures taken 3 and 4 h post ingestion. Participants' ratings of confusion and intoxication were significantly lower, and they were more willing to drive in the dehydration trial compared with one of the euhydration trials. These findings suggest that dehydration or other physiological changes associated with exercise may have an ability to influence the subjective effects of alcohol and increase the likelihood of risk-taking behaviours such as drink-driving. However, further research is required to examine the effects of alcohol under conditions of exercise-induced fluid loss in order to clarify these findings.
机译：这项研究调查了运动诱发的脱水对酒精药代动力学，主观损害等级和冒险行为的影响。 12名男性志愿者参加了3个实验试验，这些试验以至少7天的随机交叉设计完成。在一项试验中，参与者运动导致脱水〜2.5％体重减轻。对于其他试验，要求参与者处于休息和水合状态。然后在每个试验中消耗一定量的酒精，并在4小时内对参与者进行监测。自始至终收集血液（BAC）和呼气（BrAC）酒精样本并进行分析，以计算与血液酒精曲线相关的药代动力学变量。在每项试验中，还记录了总尿量，BrAC估计值以及中毒和损伤的主观评分。在任何试验条件下，酒精的药代动力学均未发现差异。饮酒后2小时，BrAC高于BAC，但在摄入后3和4小时采取的措施则较低。与其中一项水合作用试验相比，参与者在脱水试验中的混乱和中毒等级明显较低，并且他们更愿意开车。这些发现表明，与运动有关的脱水或其他生理变化可能具有影响酒精的主观效果并增加冒险行为（如酒后驾驶）的可能性的能力。但是，为了阐明这些发现，还需要进一步的研究来研究运动引起的体液流失情况下酒精的作用。

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