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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Toluene impairs learning and memory, has antinociceptive effects, and modifies histone acetylation in the dentate gyrus of adolescent and adult rats
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Toluene impairs learning and memory, has antinociceptive effects, and modifies histone acetylation in the dentate gyrus of adolescent and adult rats

机译：甲苯会损害学习和记忆力，具有抗伤害感受的作用，并会改变青春期和成年大鼠齿状回中的组蛋白乙酰化

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摘要

Toluene misuse usually initiates at an early age when the central nervous system is still immature, causing deleterious effects such as cognitive impairment. Epigenetic regulatory mechanisms have been proposed to explain long-term changes involved not only in memory, but also in toluene's actions. The aim of this study was to evaluate the effects of acute and chronic toluene exposure on learning, memory and histone acetylation in the rat hippocampus during two stages of life: adolescence and young adulthood. Because the memory tests used in this work involved object exploration and the perception of a noxious stimulus, general activity and nociception tests were also conducted. Acute and chronic toluene inhalation impaired learning, short-term and long-term memory in an object-recognition test and in an inhibitory avoidance task in both groups of age. This effect was concentration-dependent and occurred even at low toluene concentrations (1000, 2000 ppm) that were otherwise non-effective. Acute toluene inhalation produced antinociception, and tolerance to this effect developed after chronic exposure. Histone acetylation in the dentate gyrus showed differences depending on the histone, treatment and age: a single toluene exposure increased H4 acetylation in adolescents and young adult rats, whereas chronic exposure decreased H3 acetylation, but only in adults. In conclusion, this work provides evidence of toluene-induced impairment on learning, short- and long-term memory in adolescent and young adult rats, and shows that even a single toluene exposure can induce epigenetic modifications in the rat hippocampus.
机译：甲苯滥用通常在中枢神经系统仍不成熟的早期开始，引起诸如认知障碍等有害影响。已经提出表观遗传调控机制来解释不仅涉及记忆，而且涉及甲苯作用的长期变化。这项研究的目的是评估急性和慢性甲苯暴露对青春期和成年期两个生命阶段大鼠海马学习，记忆和组蛋白乙酰化的影响。由于这项工作中使用的记忆力测试涉及对象探索和有害刺激的感知，因此还进行了一般活动和伤害感受测试。两组对象的急性和慢性甲苯吸入都会损害对象识别测试和抑制性避免任务中的学习，短期和长期记忆。这种作用是浓度依赖性的，甚至在低甲苯浓度（1000、2000 ppm）下也会发生，否则无效。吸入急性甲苯会产生抗伤害感受，并且在长期暴露后会产生对此效应的耐受性。齿状回中的组蛋白乙酰化显示出差异，取决于组蛋白，治疗和年龄：一次甲苯暴露增加了青少年和成年幼鼠的H4乙酰化，而长期暴露则降低了H3乙酰化，但仅在成年人中。总之，这项工作提供了甲苯诱导的青春期和年轻成年大鼠学习，短期和长期记忆障碍的证据，并表明即使单次暴露甲苯也可以在大鼠海马中诱导表观遗传修饰。

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