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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Diazepam-induced decrease in anxiety-like behaviors of marmoset monkeys exposed to a novel open-field
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Diazepam-induced decrease in anxiety-like behaviors of marmoset monkeys exposed to a novel open-field

机译：地西p诱导的暴露于新型旷野的mar猴的焦虑样行为减少

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摘要

Unfamiliar environments can be a source of stress, fear and anxiety for marmoset monkeys. In spite of existing data, the influence of putative anxiolytics on the effects of novel environments has yet to be tested in primates. Therefore, the behavior of adult black tufted-ear marmosets to a single brief (15 min) exposure to a novel environment was analyzed in the presence and absence of diazepam (DZP). Marmosets were pre-treated with vehicle (n = 5) or diazepam (0.5 mg/kg, ip; n = 5) and submitted to a 15 min free exploration trial within a rectangular open-field arena. DZP-treated subjects, compared to vehicle controls, demonstrated significantly lower rates of (phee) contact calls and exploration, while a higher scan duration. Sojourn time in the arena's central zone was also significantly higher in the former group and sedation was not observed. Thus, pre-treatment with the benzodiazepine DZP decreased several anxiety-related behaviors induced by subjecting the marmosets to a new environment. The results also indicate that, as with rodent subjects, the open-field may provide a useful simple paradigm for assessing anxiety-like behaviors in this primate and, as such, constitutes a unique opportunity for direct comparative studies between rodents and marmoset monkeys in terms of anxiety and/or sedation.
机译：陌生的环境可能会给mo猴带来压力，恐惧和焦虑。尽管已有数据，但尚待在灵长类动物中检验推定的抗焦虑药对新型环境的影响。因此，分析了在有地西epa（DZP）存在和不存在的情况下，成年黑色簇绒耳朵mar猴在短暂短暂（15分钟）下暴露于新环境的行为。 mos猴用媒介物（n = 5）或地西epa（0.5 mg / kg，ip; n = 5）进行了预处理，并在长方形的露天场地进行了15分钟的免费勘探试验。与车辆对照相比，DZP治疗的受试者表现出（phe）接触呼叫和探索的比率显着降低，而扫描时间则更长。前者在竞技场中央区域的停留时间也明显更长，且未观察到镇静作用。因此，用苯二氮卓DZP进行的预处理减少了将mar猴置于新环境中引起的几种与焦虑相关的行为。结果还表明，与啮齿类动物一样，开阔视野可以为评估该灵长类动物的焦虑样行为提供有用的简单范例，因此，就啮齿类动物和mar猴而言，这为直接比较研究提供了独特的机会焦虑和/或镇静。

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