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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Demand for cocaine and food over time.
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Demand for cocaine and food over time.

机译：随着时间的推移对可卡因和食物的需求。

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When reinterpreted, data from Ahmed and Koob [Ahmed, S.H., Koob, G.F., Transition from moderate to excessive drug intake: Change in hedonic set point. Science 1998; 282:298-301.] show that the reinforcing strength of cocaine, an inessential good, increases with experience. However, no such effect obtains with a homeostatically regulated good such as food. The present study evaluated whether this difference could serve to distinguish abused drugs from biologically necessary goods. In Experiment 1, five rats from Christensen, Silberberg, Hursh, Huntsberry and Riley [Christensen, C.J., Silberberg, A., Hursh, S.R., Huntsberry, M.E., Riley, A.L., Essential value of cocaine and food in rats: tests of the exponential model of demand. Psychopharmacology 2008;198(2):221-229.] earned cocaine under a Fixed-Ratio 3 schedule for 7 sessions. Thereafter, in a demand procedure identical to that in Christensen et al., demand was re-assessed by measuring consumption at Fixed Ratios between 3 and 560. In Experiment 2, five different rats from Christensen et al. had their food demand curves re-determined using an identical procedure as the first. When fit with the exponential model, the second determination of cocaine demand in Experiment 1 showed greater essential value than the first, indicating that strength increased with cocaine exposure. In Experiment 2, the re-determined food demand curves showed no change from their initial determination. These results show that the strength of cocaine, but not food, increases with increased experience. Measures of time-based changes in essential value may serve as a basis for distinguishing addictive from non-addictive reinforcers.
机译：重新解释后，来自Ahmed和Koob的数据[Ahmed，S.H.，Koob，G.F.，从中等药物摄入过渡到过量药物摄入：享乐设定点的变化。科学1998; 282：298-301。]表明，可卡因的一种非必需品的增强强度随经验的增加而增加。但是，用稳态调节的食品如食物不能获得这种效果。本研究评估了这种差异是否可以用来区分滥用药物和生物必需品。在实验1中，五只老鼠来自克里斯滕森，席尔伯伯格，赫尔什，亨茨伯里和赖利[克里斯滕森，CJ，席尔伯伯格，A。，赫尔什，SR，亨茨伯里，ME，赖利，阿拉巴马州，可卡因和食物的基本价值：需求的指数模型。 [Psychopharmacology 2008; 198（2）：221-229。]在固定比率3的计划下进行了7次锻炼，获得了可卡因。此后，按照与Christensen等人相同的需求程序，通过以3至560的固定比率测量消耗量来重新评估需求。在实验2中，有5位来自Christensen等人的不同大鼠进行了评估。用与第一个相同的程序重新确定了他们的食物需求曲线。当与指数模型拟合时，实验1中对可卡因需求的第二次确定显示出比第一项更大的基本值，表明强度随可卡因暴露而增加。在实验2中，重新确定的食物需求曲线与最初确定的曲线没有变化。这些结果表明，可卡因而不是食物的强度随着经验的增加而增加。基于时间的基本价值变化的度量可以用作区分成瘾者和非成瘾者的基础。

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