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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Central administration of IL-1 reduces anxiety and induces sickness behaviour in rats.
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Central administration of IL-1 reduces anxiety and induces sickness behaviour in rats.

机译：IL-1的中央给药可减轻大鼠的焦虑并诱发疾病行为。

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In the present study, we examined the effects of various doses of recombinant human interleukin-1beta on anxiety-like behaviour, on body temperature, and on behavioural changes typical of sick animals. First, we assessed the behaviour of rats in the elevated plus-maze before and 20 min after intracerebroventricular injection of IL-1 at six doses ranging from 0.001 to 100 ng. After treatment with 0.1 and 100 ng IL-1, animals exhibited different anxiety levels. The dose effect on behavioural performance in the plus-maze appears to be nonlinear (parabolic function), with the highest effects near a 0.1-ng dose and the lowest near doses of 0.0 and 100 ng. In a second set of experiments, we examined the effects of doses of 0.1 and 100 ng IL-1 (which had the most pronounced effects on performance in the plus-maze) on physical parameters over a 24-h period. Using radiotelemetry we measured body temperature, locomotor activity, food intake, and water consumption: a) in animals kept under basal resting conditions, and b) in animals exposed to a novel environment prior to administration of IL-1. Both doses evoked a fever response and reduced locomotor activity, but the increase in body temperature did not correlate with the decrease in locomotor activity and both effects did not occur at the time of behavioural testing. Taken together, our data indicate that central administration of IL-1 has anxiolytic-like properties.
机译：在本研究中，我们检查了各种剂量的重组人白介素-1β对焦虑样行为，体温和典型患病动物行为变化的影响。首先，我们在脑室内注射0.001至100 ng六种剂量的IL-1之前和之后20分钟评估了高迷宫中大鼠的行为。用0.1和100 ng IL-1治疗后，动物表现出不同的焦虑水平。剂量对正迷宫中的行为表现的剂量影响似乎是非线性的（抛物线函数），在0.1 ng剂量附近最高，而在0.0和100 ng剂量附近最低。在第二组实验中，我们检查了0.1和100 ng IL-1剂量（对正迷宫中的性能影响最明显）在24小时内对物理参数的影响。使用无线电遥测技术，我们测量了体温，运动能力，食物摄入和水消耗：a）在基础休息条件下饲养的动物，b）在施用IL-1之前暴露于新环境的动物。两种剂量均引起发烧反应并降低运动能力，但体温升高与运动能力降低不相关，并且在行为测试时两种作用均未发生。两者合计，我们的数据表明IL-1的中央管理具有抗焦虑的性质。

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