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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Dorsal raphe and substantia nigra response to flumazenil in diazepam-dependent rats.
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Dorsal raphe and substantia nigra response to flumazenil in diazepam-dependent rats.

机译：地西epa依赖性大鼠对氟马西尼的背缝和黑质反应。

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摘要

Flumazenil (FLU; 25 micrograms) and DMSO-vehicle were focally injected (1 microliter) into the substantia nigra (SN) and the dorsal raphe nucleus (DR) in rats chronically implanted with silastic capsules containing diazepam (DZ; 540 mg/week). FLU precipitated an abstinence syndrome in the SN as indicated by a significant abstinence score, several abstinence signs and reduced total power of the fast frequency bands of the electroencephalogram (EEG) in the injections sites frontal cortex, (FC) and hippocampus (H). In contrast, FLU did not produce an abstinence syndrome in the DR, and its effect on the power of the EEG in DR, FC and H was not significantly different from that of the DMSO-vehicle. The data show regional heterogeneity in the response of the SN and the DR to chronic DZ treatment in terms of a focally precipitated abstinence syndrome.
机译：将氟马西尼（FLU; 25微克）和DMSO车辆集中注入（1微升）慢性植入含有地西epa的硅橡胶胶囊的大鼠黑质（SN）和背沟核（DR）（DZ; 540 mg /周） 。 FLU在SN的戒断综合征中表现出明显的戒断分数，若干戒断体征并降低了大脑皮层（FC）和海马（H）注射部位的脑电图（EEG）的快速频段的总功率，表明该综合征。相反，FLU在DR中不产生戒酒综合症，并且其对DR，FC和H中的EEG的影响与DMSO车辆没有显着差异。数据显示，就局灶性戒断综合征而言，SN和DR对慢性DZ治疗的反应存在区域异质性。

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