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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of sodium azide on motor activity, motor coordination, and learning.
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Effects of sodium azide on motor activity, motor coordination, and learning.

机译：叠氮化钠对运动活动，运动协调和学习的影响。

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摘要

Because of the proposed importance of cytochrome oxidase in some neurological disorders, an inhibitor of this enzyme was evaluated in a battery of tests measuring exploration, motor coordination, and learning. Mice injected with sodium azide (6 or 12 mg/kg) were slower to initiate a response in a T maze and had less rears in a small chamber than mice injected with placebo. Drugged mice did not alternate spontaneously even at a minimal retention interval (0 min), but were not impaired in water maze spatial and visual discrimination learning tasks. No group differences emerged in terms of horizontal motor activity and its habituation, number of grooming episodes, and motor coordination. These results indicate that azide-induced slowing of motor activity is situation-specific and is accompanied by abnormalities in choice behavior in a T maze.
机译：由于建议的细胞色素氧化酶在某些神经系统疾病中的重要性，因此在一系列探索，运动协调和学习的测试中对该酶的抑制剂进行了评估。与注射安慰剂的小鼠相比，注射有叠氮化钠（6或12 mg / kg）的小鼠在T迷宫中启动反应的速度较慢，并且在小室内的后部较少。服药的小鼠即使在最小保留间隔（0分钟）内也不会自发交替，但在水迷宫空间和视觉辨别力学习任务中并未受到损害。在水平运动活动及其习惯，修饰次数和运动协调方面，没有出现群体差异。这些结果表明，叠氮化物诱导的运动活动减慢是特定情况的，并伴有T迷宫中选择行为的异常。

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