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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Time course analysis of the discriminative stimulus effects of the optical isomers of 3,4-methylenedioxymethamphetamine (MDMA).
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Time course analysis of the discriminative stimulus effects of the optical isomers of 3,4-methylenedioxymethamphetamine (MDMA).

机译：3,4-亚甲基二氧基甲基苯丙胺（MDMA）旋光异构体的鉴别刺激效果的时程分析。

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摘要

The present study examined the discriminative stimulus effects of the MDMA optical isomers administered at different presession injection intervals. In the first experiment, male Sprague-Dawley rats were trained in a two-lever, food-reinforced operant procedure to discriminate either (+)-MDMA (1.25 mg/kg) or (-)-MDMA (3.50 mg kg) at either 20 or 90 min following injection. Animals administered (+)-MDMA or saline 90 min before training sessions failed to attain the discrimination criteria after 73 training sessions, whereas (-)-MDMA successfully established discriminative stimulus control at both the 20 min and the 90 min postinjection intervals. (+)-Amphetamine did not substitute for either isomer, although a significant amount of drug-appropriate responding occurred in animals trained to discriminate (+)-MDMA at 20 min and (-)-MDMA at 90 min. Sch 39166 partially reduced the discrimination of (+)-MDMA at 20 min and (-)-MDMA at 90 min, although this effect was not dose dependent. Sch 39166 had no effecton animals trained to discriminate (-)-MDMA at 20 min. Haloperidol did not alter the discrimination of (+)-MDMA at 20 min but partially reduced the discriminative stimulus control of (-)-MDMA at 20 min and (-)-MDMA at 90 min. Fenfluramine substituted for both isomers of MDMA. Pirenpirone completely blocked the discriminative stimulus effects of (-)-MDMA at 20 min, although (+)-MDMA at 20 min and (-)-MDMA at 90 min were only partly blocked. WAY 100,135 had little effect on drug-appropriate responding; however, the discrimination of (+)-MDMA at 20 min was partly reduced by this 5-HT1A antagonist. In a second experiment, rats trained to discriminate (+)-MDMA (1.5 mg/kg) or (-)-MDMA (3.0 mg/kg) from saline were administered substitution tests with both isomers 20, 60, 90 and 120 min after injection. Results confirmed those of the first experiment that (+)-MDMA appears to have a shorter duration of action than (-)-MDMA. These results are discussed in light of the training doses employed.
机译：本研究检查了在不同的治疗前注射间隔给予的MDMA光学异构体的歧视性刺激作用。在第一个实验中，对雄性Sprague-Dawley大鼠进行了两杆食物强化操作程序的训练，以区分（+）-MDMA（1.25 mg / kg）或（-）-MDMA（3.50 mg kg）注射后20或90分钟。在训练前90分钟服用（+）-MDMA或生理盐水的动物在73次训练后未能达到判别标准，而（-）-MDMA在注射后20分钟和90分钟间隔成功建立了区分性刺激控制。 （+）-苯丙胺不能替代任何一种异构体，尽管在训练中能够在20分钟时分辨出（+）-MDMA和在90分钟时分辨出（-）-MDMA的动物中发生了相当数量的药物反应。 Sch 39166在20分钟时部分降低了（+）-MDMA的分辨力，在90分钟时降低了（-）-MDMA的分辨力，尽管这种作用与剂量无关。 Sch 39166对经过训练在20分钟时能分辨（-）-MDMA的动物没有影响。氟哌啶醇在20分钟时不会改变（+）-MDMA的辨别力，但会部分减少20分钟时（-）-MDMA和90分钟时（-）-MDMA的歧视性刺激控制。芬氟拉明取代了MDMA的两个异构体。尽管在20分钟时（+）-MDMA和在90分钟时（-）-MDMA仅被部分阻断，但哌仑吡酮在20分钟时完全阻断了（-）-MDMA的歧视性刺激作用。 WAY 100,135对适当药物的反应影响很小;但是，此5-HT1A拮抗剂可部分减少（+）-MDMA在20分钟时的辨别力。在第二个实验中，对受过训练以从盐水中区分（+）-MDMA（1.5 mg / kg）或（-）-MDMA（3.0 mg / kg）的大鼠进行替代测试，分别在20、60、90和120分钟后对两种异构体进行测试注射。结果证实了第一个实验的结果，（+）-MDMA的作用持续时间似乎比（-）-MDMA的作用时间短。根据所采用的训练剂量讨论了这些结果。

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