• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Time course of the attenuation effect of repeated antipsychotic treatment on prepulse inhibition disruption induced by repeated phencyclidine treatment.
【24h】

Time course of the attenuation effect of repeated antipsychotic treatment on prepulse inhibition disruption induced by repeated phencyclidine treatment.

机译：重复抗精神病药物治疗对通过反复苯环利定治疗引起的前脉冲抑制破坏的衰减作用的时程。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Antagonism of prepulse inhibition (PPI) deficits produced by psychotomimetic drugs has been widely used as an effective tool for the study of the mechanisms of antipsychotic action and identifying potential antipsychotic drugs. Many studies have relied on the acute effect of a single administration of antipsychotics, whereas patients with schizophrenia are treated chronically with antipsychotic drugs. The clinical relevance of acute antipsychotic effect in this model is still an open question. In this study, we investigated the time course of repeated antipsychotic treatment on persistent PPI deficit induced by repeated phencyclidine (PCP) treatment. After a baseline test with saline, male Sprague-Dawley rats were repeatedly injected with either vehicle, haloperidol (0.05mg/kg), clozapine (5.0 or 10.0mg/kg), olanzapine (2.0mg/kg), risperidone (1.0mg/kg) or quetiapine (10mg/kg), followed by PCP (1.5mg/kg, sc) and tested for PPI once daily for 6 consecutive days. A single injection of PCP disrupted PPI and this effect was maintained with repeated PCP injections throughout the testing period. Acute clozapine, but not other antipsychotic drugs, attenuated acute PCP-induced PPI disruption at both tested doses. With repeated treatment, clozapine and quetiapine maintained their attenuation, while risperidone enhanced its effect with a significant reduction of PCP-induced disruption toward the end of treatment period. In contrast, repeated haloperidol and olanzapine treatments were ineffective. The PPI effects of these drugs were more conspicuous at a higher prepulse level (e.g. 82dB) and were dissociable from their effects on startle response and general activity. Overall, the repeated PCP-PPI model appears to be a useful model for the study of the time-dependent antipsychotic effect, and may help identify potential treatments that have a quicker onset of action than current antipsychotics.
机译：拟精神病药物产生的前冲抑制（PPI）拮抗作用已被广泛用作研究抗精神病药物作用机制和鉴定潜在抗精神病药物的有效工具。许多研究都依赖于单剂抗精神病药的急性作用，而精神分裂症患者则需要长期使用抗精神病药治疗。在这种模型中，急性抗精神病药物的临床意义仍然是一个悬而未决的问题。在这项研究中，我们调查了反复抗精神病药物治疗对反复苯环利定（PCP）治疗引起的持续PPI缺乏的时间过程。在用盐水进行基线测试之后，雄性Sprague-Dawley大鼠被反复注射媒介物，氟哌啶醇（0.05mg / kg），氯氮平（5.0或10.0mg / kg），奥氮平（2.0mg / kg），利培酮（1.0mg / kg） kg）或喹硫平（10mg / kg），然后是PCP（1.5mg / kg，sc），并连续6天每天测试一次PPI。一次注射PCP会破坏PPI，并且在整个测试期间重复注射PCP可以保持这种效果。两种试验剂量的急性氯氮平均能减轻急性PCP诱导的PPI破坏，但不能抑制其他抗精神病药物。经过反复治疗，氯氮平和喹硫平维持其衰减，而利培酮则在治疗期结束时增强了其作用，并显着减少了PCP诱导的破坏。相反，重复的氟哌啶醇和奥氮平治疗无效。这些药物的PPI效应在较高的脉冲前水平（例如82dB）时更为明显，并且与它们对惊吓反应和一般活动的影响是分离的。总体而言，重复的PCP-PPI模型似乎是研究时间依赖性抗精神病药物作用的有用模型，并且可能有助于确定比目前的抗精神病药物起效快的潜在治疗方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号