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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Acute blockade of CB1 receptor leads to reinstatement of MDMA-induced conditioned place preference.
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Acute blockade of CB1 receptor leads to reinstatement of MDMA-induced conditioned place preference.

机译：CB1受体的急性阻断导致MDMA诱导的条件性位置偏好的恢复。

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摘要

Cannabis is one of the drugs most commonly consumed in combination with ecstasy (3,4-methylenedioxymethamphetamine, MDMA). Although numerous studies have attempted to further our understanding of the role of the cannabinoid system in drug abuse, few have focused on how it influences the rewarding effects of MDMA. The aim of the present study was to evaluate the role of the CB1 cannabinoid receptor in vulnerability to reinstatement of a MDMA-induced conditioned place preference (CPP). Mice were first conditioned with 5mg/kg of MDMA. Once the preference had been extinguished, a priming dose of MDMA, alone or plus the CB1 cannabinoid agonist WIN 55,212-2 (0.1 and 0.5mg/kg) or the CB1 cannabinoid antagonist SR 141716A (0.3mg/kg), was administered on alternate days. The CB1 receptor antagonist, alone or with any of the priming doses of MDMA, induced reinstatement of the preference. In contrast, WIN 55,212-2 had no effect on reinstatement of the MDMA-induced CPP when administered alone, but potentiated the effects of subthreshold priming doses of MDMA. These results highlight the important role of the CB1 receptor in vulnerability to reinstatement of drug-seeking behavior and point to the importance of the endocannabinoid system in the addictive potential of MDMA.
机译：大麻是与摇头丸（3,4-亚甲基二氧基甲基苯丙胺，MDMA）合用时最常使用的药物之一。尽管许多研究试图加深我们对大麻素系统在药物滥用中的作用的了解，但很少有人关注它如何影响MDMA的有益作用。本研究的目的是评估CB1大麻素受体在恢复MDMA诱导的条件性位置偏爱（CPP）的脆弱性中的作用。首先用5mg / kg的MDMA使小鼠适应。取消偏好后，单独或加用CB1大麻素激动剂WIN 55,212-2（0.1和0.5mg / kg）或CB1大麻素拮抗剂SR 141716A（0.3mg / kg）的初始剂量的MDMA天。单独使用CB1受体拮抗剂或与任何初次剂量的MDMA结合，均可引起偏好的恢复。相反，当单独给药时，WIN 55,212-2对MDMA诱导的CPP的恢复没有作用，但是增强了亚阈值引发剂量的MDMA的作用。这些结果突显了CB1受体在恢复寻药行为的脆弱性中的重要作用，并指出内源性大麻素系统在MDMA的成瘾潜力中的重要性。

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