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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The interactive effects of environmental enrichment and extinction interventions in attenuating cue-elicited cocaine-seeking behavior in rats.
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The interactive effects of environmental enrichment and extinction interventions in attenuating cue-elicited cocaine-seeking behavior in rats.

机译：环境富集和灭绝干预措施在减弱提示引起的可卡因寻求大鼠行为中的相互作用。

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Cues associated with cocaine can elicit craving and relapse. Attempts have been made to employ extinction therapy, which is aimed at attenuating the incentive motivational effects of cocaine cues, as a treatment for cocaine addiction; however, this approach has been largely unsuccessful perhaps due to the inability to extinguish all cues associated with cocaine use while in a clinic. Recently, environmental enrichment (EE) during abstinence has been proposed as a strategy to attenuate cue-elicited cocaine craving. The present study used an animal model to examine whether the utility of extinction toward attenuating cue-elicited cocaine-seeking behavior could be enhanced by also providing EE. All rats were trained to self-administer cocaine while housed in isolated conditions and then subsequently underwent 17 days of forced abstinence, during which they were either housed in pairs or under EE and they either received daily 1-h extinction sessions or similar handling without exposure to the self-administration environment. Following this intervention period, all rats were tested for cue-elicited cocaine-seeking behavior. To examine whether effects of these interventions persist, all rats were subsequently single-housed for an additional 7-day forced abstinence period, followed by a second test for cue-elicited cocaine-seeking behavior. We found that although daily extinction training and EE each attenuated subsequent cue-elicited cocaine-seeking behavior, the combined treatment of extinction training+EE completely prevented it. However, once these interventions were discontinued, their protective effects diminished. These findings suggest that combining behavioral therapy approaches may improve outcomes; however, future work is needed to improve the longevity of these strategies beyond their implementation.
机译：与可卡因有关的提示会引起渴望和复发。已经尝试使用消光疗法，其目的是减弱可卡因提示的激励性动机作用，作为可卡因成瘾的一种治疗方法。但是，这种方法在很大程度上没有成功，可能是由于无法在诊所中扑灭与可卡因使用有关的所有提示。近来，禁欲期间的环境富集（EE）已被提议作为减轻提示引起的可卡因渴望的策略。本研究使用动物模型来研究是否通过提供EE来增强灭绝对减弱线索诱发的可卡因寻求行为的效用。对所有大鼠进行训练，使其在隔离条件下饲养时自我给药可卡因，然后进行17天的强迫戒断，在此期间将它们成对饲养或在EE下饲养，每天接受1小时的灭绝活动或类似的处理而无需暴露自我管理环境。在这个干预期之后，测试所有大鼠的提示诱发的可卡因寻找行为。为了检查这些干预措施的效果是否持续，随后将所有大鼠单笼饲养额外的7天强迫戒断期，然后进行第二次提示引起的可卡因寻求行为的测试。我们发现，尽管每天的灭绝训练和EE都减弱了随后的提示诱发的可卡因寻找行为，但灭绝训练+ EE的联合治疗完全阻止了它。但是，一旦停止这些干预措施，其保护作用就会减弱。这些发现表明，结合行为疗法可以改善治疗效果。但是，除了这些策略的实施之外，还需要进一步的工作来提高这些策略的寿命。

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