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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Maternal prolactin inhibition at the end of lactation affects learning/memory and anxiety-like behaviors but not novelty-seeking in adult rat progeny.
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Maternal prolactin inhibition at the end of lactation affects learning/memory and anxiety-like behaviors but not novelty-seeking in adult rat progeny.

机译：泌乳结束时母体催乳素的抑制会影响成年大鼠后代的学习/记忆和焦虑样行为，但不会影响其寻求新颖性。

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Maternal hypoprolactinemia at the end of lactation in rats reduces milk production and is associated with offspring's malnutrition. Since malnutrition during development is also known to have long lasting effects on cognition and emotion, in the present study we tested the hypothesis that maternal hypoprolactinemia, induced by bromocriptine treatment, at the end of the lactating period affects memory/learning, novelty-seeking and anxiety-like behaviors in adult male Wistar rats using, respectively, the radial arm water maze (RAWM), the hole board (HB) arena and the elevated plus-maze (EPM). We also analyzed serum corticosterone and thyroid hormone levels at postnatal day (PN) 21. Lactating dams were treated with bromocriptine (BRO, 1mg twice a day, inhibiting prolactin) or saline from PN19 to 21 (the last 3 days of lactation). BRO offspring had hypercorticosteronemia and hypothyroidism at PN21. In the RAWM, reductions in latency observed in CON rats were initially more accentuated than in BRO ones. By the end of the testing period, latencies became similar between groups. No difference was observed between groups regarding the number of nose-pokes in the HB. In the EPM, BRO rats stayed less time in and had fewer entries into the open-arms than CON ones. This pattern of results indicates that maternal bromocriptine treatment at the end of the lactating period results in poorer memory/learning performance and in higher levels of anxiety-like behavior in the adult offspring, demonstrating that even a relatively short period of malnutrition during development can have long lasting detrimental effects regarding cognition and emotion.
机译：哺乳期末的母体泌乳素不足症会降低产奶量，并与后代营养不良有关。由于发育过程中的营养不良也已对认知和情绪产生长期影响，因此在本研究中，我们检验了以下假设：在哺乳期结束时，由溴隐亭治疗引起的母亲泌乳素不足会影响记忆/学习，寻求新事物和成年雄性Wistar大鼠使用rats臂水迷宫（RAWM），孔板（HB）竞技场和高架迷宫（EPM）时的焦虑样行为。我们还分析了出生后第21天的血清皮质类固醇和甲状腺激素水平。用PN19到21（泌乳的最后3天）用溴隐亭（BRO，每天两次，每天两次，抑制催乳素）或生理盐水处理哺乳期大坝。 BRO后代在PN21有高皮质激素血症和甲状腺功能低下症。在RAWM中，与BRO相比，最初在CON大鼠中观察到的潜伏期减少更为明显。到测试阶段结束时，组之间的延迟变得相似。两组之间在HB中的鼻戳数量上没有观察到差异。在EPM中，与CON相比，BRO大鼠停留时间更少，进入开放式手臂的次数更少。这种结果模式表明，母乳溴隐亭在哺乳期结束时的治疗会导致成年后代记忆力/学习能力下降，焦虑样行为水平更高，这表明即使发育过程中营养不良的时间相对较短关于认知和情感的长期有害影响。

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