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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Neuropeptide Y (NPY)-induced reductions in alcohol intake during continuous access and following alcohol deprivation are not altered by restraint stress in alcohol-preferring (P) rats.
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Neuropeptide Y (NPY)-induced reductions in alcohol intake during continuous access and following alcohol deprivation are not altered by restraint stress in alcohol-preferring (P) rats.

机译：在偏好酒精的（P）大鼠中，束缚应激不会改变神经肽Y（NPY）引起的持续获取和酒精剥夺后酒精摄入的减少。

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摘要

Administration of neuropeptide Y (NPY) reduces anxiety-like behavior and alcohol intake in alcohol-preferring rats. The present experiment examined whether the effects of NPY on alcohol drinking are modulated by stress exposure during continuous access or following ethanol deprivation. Female P rats underwent 6 weeks of continuous access to 15% v/v ethanol and water prior to intracerebroventricular (ICV) cannula implantation. Deprived rats underwent two cycles of 5 days of ethanol exposure followed by 2 days of ethanol deprivation, while non-deprived rats had uninterrupted access to ethanol. Stressed rats in both ethanol access groups were exposed to restraint stress for 1h 4-6h after ethanol was removed from the deprived group in both cycles. ICV infusions of 5.0 mug NPY or aCSF were administered 48 h following the deprivation/stress procedure, after which ethanol was returned. Rats showed increased ethanol intake following ethanol deprivation compared to non-deprived controls. Food and water intake were increased, while ethanol intake was decreased, in rats infused with NPY. Stress did not increase ethanol intake or alter the response to NPY. Although no stress effects were found, the present experiment replicates previous findings regarding the effectiveness of NPY in reducing ethanol consumption. Future studies aimed at determining the extent to which stress may affect relapse to ethanol drinking and response to NPY would benefit from implementing different stress paradigms and varying the pattern of ethanol access.
机译：神经肽Y（NPY）的使用可减少偏爱酒精的大鼠的焦虑样行为和酒精摄入量。本实验检查了NPY对饮酒的影响是否受到连续获取过程中或乙醇剥夺后的压力暴露的调节。雌性P大鼠在植入脑室内（ICV）套管之前连续6周接受15％v / v乙醇和水。被剥夺的大鼠经历两个周期，即乙醇暴露5天，然后剥夺乙醇2天，而未被剥夺的大鼠则不间断地获取乙醇。在两个周期中，从被剥夺的组中去除乙醇后，两个乙醇访问组中的应激大鼠都受到束缚压力1h 4-6h。剥夺/应激程序后48小时，给予5.0杯NPY或aCSF的ICV输液，然后返回乙醇。与非剥夺对照组相比，剥夺乙醇后大鼠的乙醇摄入量增加。在注入NPY的大鼠中，食物和水的摄入增加，而乙醇的摄入减少。压力并没有增加乙醇的摄入或改变对NPY的反应。尽管未发现压力影响，但本实验重复了有关NPY减少乙醇消耗有效性的先前发现。未来的研究旨在确定压力在多大程度上可能影响饮酒的复发和对NPY的反应，这将受益于实施不同的压力范式和改变乙醇获取方式。

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