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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of GABA ligands injected into the nucleus accumbens shell on fear/anxiety-like and feeding behaviours in food-deprived rats
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Effects of GABA ligands injected into the nucleus accumbens shell on fear/anxiety-like and feeding behaviours in food-deprived rats

机译：伏隔核壳中注射的GABA配体对食物匮乏大鼠恐惧/焦虑样和进食行为的影响

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In an attempt to establish a relationship between food intake and fear/anxiety-related behaviours, the goal of this study was to investigate the effect of bilateral injections of GABAA (Muscimol, MUS, doses 25 and 50 ng/side) and GABAB (Baclofen, BAC, doses 32 and 64 ng/side) receptor agonists in the nucleus accumbens shell (AcbSh) on the level of fear/anxiety-like and feeding behaviours in 24 h food-deprived rats. The antagonists of GABAA (Bicuculline, BIC, doses 75 and 150 ng/side) and GABAB (Saclofen, SAC, doses 1.5 and 3 μg/side) were also tested. The results indicated that the total number of risk assessment behaviour decreased after the injection of both doses of GABAA agonist (MUS) into the AcbSh of 24 h food-deprived rats exposed to elevated plus maze. Similar results were obtained after treatment with both doses of GABAB (BAC) agonist in the AcbSh. These data indicated that the activation of both GABAA and GABAB receptors within the AcbSh caused anxiolysis in 24 h food-deprived rats. In addition, feeding behaviour (food intake, feeding latency and feeding duration) remained unchanged after treatment with both GABA agonists. In contrast, both food intake and feeding duration decreased after injections of both doses of BIC (GABAA antagonist), while the feeding latency remained unchanged after treatment with both GABA antagonists in the AcbSh of 24 h food-deprived rats. The treatment with SAC (GABAB antagonist) did not affect feeding behaviour. Collectively, these data suggest that emotional changes evoked by pharmacological manipulation of the GABA neurotransmission in the AcbSh are not linked with changes in food intake.
机译：为了建立食物摄入量与恐惧/焦虑相关行为之间的关系，本研究的目的是研究双侧注射GABAA（麝香酚，MUS，剂量为25和50 ng /侧）和GABAB（巴氯芬）的作用。 ，BAC，伏隔核壳（AcbSh）中剂量为32和64 ng / side）的受体激动剂对24小时食物缺乏的大鼠的恐惧/焦虑样和进食行为水平。还测试了GABAA（双瓜氨酸，BIC，剂量为75和150 ng /侧）和GABAB（沙氯芬，SAC，剂量为1.5和3μg/侧）的拮抗剂。结果表明，将两种剂量的GABAA激动剂（MUS）注入暴露于高架迷宫的24 h食物匮乏大鼠的AcbSh中后，风险评估行为的总数减少。在两种剂量的AcbSh中使用两种剂量的GABAB（BAC）激动剂治疗后，都获得了相似的结果。这些数据表明，AcbSh中GABAA和GABAB受体的激活引起了24小时食物缺乏大鼠的抗焦虑作用。此外，两种GABA激动剂治疗后的进食行为（食物摄入，进食潜伏期和进食时间）保持不变。相比之下，注射两种剂量的BIC（GABAA拮抗剂）后，进食和进食时间均减少，而两种GABA拮抗剂处理后的24 h禁食大鼠AcbSh中的进食潜伏期保持不变。 SAC（GABA B拮抗剂）的治疗不影响喂养行为。总体而言，这些数据表明，通过AcbSh中GABA神经传递的药理处理引起的情绪变化与食物摄入的变化无关。

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