• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The antinociceptive activity of harmicine on chemical-induced neurogenic and inflammatory pain models in mice
【24h】

The antinociceptive activity of harmicine on chemical-induced neurogenic and inflammatory pain models in mice

机译：毒品对化学诱导的小鼠神经源性和炎症性疼痛模型的镇痛作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Harmicine is a β-carboline alkaloid isolated and identified as a major active compound present in many plant species and marine invertebrates. This alkaloid exhibits a wide spectrum of pharmacological activities, including antispasmodic, antipyretic, and anticancer properties. This report described the antinociceptive properties of harmicine by means of chemical experimental models in order to evaluate the use for pain relief. The results demonstrating the potential analgesic properties of harmicine administered intraperitoneally were shown with the writhing test, reducing writhes around 60% (1 mg/kg), and in the formalin test, where harmicine was more effective toward neurogenic (reducing reaction time around 60%, 1 mg/kg) than inflammatory (68% reduction, 10 mg/kg) pain responses. Furthermore, these effects may operate via vanilloid receptors as revealed by the capsaicin test (41% reduction, with 3 mg/kg), as well as via peripheral glutamate receptors as shown by the glutamate test (50% reduction, with 1 mg/kg). Moreover, the opioid antagonist naloxone hydrochloride did not interfere in the antinociceptive properties of harmicine in the writhing test, revealing that this effect may not have a relationship with the opioid systems. Concluding, this report highlights harmicine as a new candidate to be used as analgesic in the future. Therefore, further studies are being undertaken in order to understand the exact mechanisms involved with the antinociceptive properties of harmicine.
机译：谐mic素是一种β-咔啉生物碱，被分离并鉴定为存在于许多植物物种和海洋无脊椎动物中的主要活性化合物。这种生物碱具有广泛的药理活性，包括解痉，解热和抗癌特性。该报告通过化学实验模型描述了甜菜碱的镇痛特性，以评估其缓解疼痛的用途。扭体试验显示了腹膜内施用甜菜碱的潜在镇痛特性，扭结试验可减少约60％（1 mg / kg）的扭伤，福尔马林试验中的结果表明，甜菜碱对神经源性更有效（缩短反应时间约60％） ，1 mg / kg）比炎性（缓解68％，10 mg / kg）疼痛反应好。此外，这些作用可能通过辣椒素测试显示的类香草体受体（减少3％/ mg，降低41％），以及通过谷氨酸测试显示的周围谷氨酸受体（减少1％/ mg，降低50％）起作用。 ）。此外，在扭体试验中，阿片类药物拮抗剂纳洛酮盐酸盐不干扰甜菜碱的镇痛特性，表明该作用可能与阿片类药物系统无关。最后，本报告重点介绍了作为未来镇痛药的新候选药物。因此，正在进行进一步的研究，以了解与药物的抗伤害感受特性有关的确切机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号