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L-theanine partially counteracts caffeine-induced sleep disturbances in rats

机译:L-茶氨酸可部分抵消咖啡因引起的大鼠睡眠障碍

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L-theanine has been reported to inhibit the excitatory effects of caffeine. The present study examined the effects of L-theanine on caffeine-induced sleep disturbances in rats. Rats received the following drug pairings: saline and saline (Control), 7.5 mg/kg caffeine and saline, or 7.5 mg/kg of caffeine followed by various doses of L-theanine (22.5, 37.5, 75, or 150 mg/kg). Vigilance states were divided into: wakefulness (W), transition to slow-wave sleep (tSWS), slow-wave sleep (SWS), and rapid-eye-movement sleep (REMS). Caffeine significantly increased the duration of W and decreased the duration of SWS and REMS compared to the Control. Although L-theanine failed to reverse the caffeine-induced W increase, at 22.5 and 37.5 mg/kg (but not at 75 and 150 mg/kg), it significantly reversed caffeine-induced decreases in SWS. In conclusion, low doses of L-theanine can partially reverse caffeine-induced reductions in SWS; however, effects of L-theanine on caffeine-induced insomnia do not appear to increase dose-dependently.
机译:据报道,L-茶氨酸可抑制咖啡因的兴奋作用。本研究检查了L-茶氨酸对咖啡因诱发的大鼠睡眠障碍的影响。大鼠接受以下药物配对:生理盐水和生理盐水(对照),7.5 mg / kg咖啡因和生理盐水或7.5 mg / kg咖啡因,然后是各种剂量的L-茶氨酸(22.5、37.5、75或150 mg / kg) 。警觉状态分为:清醒(W),过渡到慢波睡眠(tSWS),慢波睡眠(SWS)和快速眼动睡眠(REMS)。与对照相比,咖啡因可显着增加W的持续时间,并减少SWS和REMS的持续时间。虽然L-茶氨酸不能逆转咖啡因引起的W增加,但以22.5和37.5 mg / kg(而不是75和150 mg / kg)不能逆转咖啡因引起的SWS下降。总之,低剂量的L-茶氨酸可以部分逆转咖啡因引起的SWS降低。然而,L-茶氨酸对咖啡因引起的失眠的作用似乎没有剂量依赖性地增加。

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