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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Behavioral sensitization to apomorphine in adult rats exposed to cocaine during the preweaning period: a preliminary study.
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Behavioral sensitization to apomorphine in adult rats exposed to cocaine during the preweaning period: a preliminary study.

机译：断奶前暴露于可卡因的成年大鼠对阿扑吗啡的行为敏化：一项初步研究。

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Sixty-day-old rats treated with cocaine (50 mg/kg SC) during postnatal days (PND) 11-20 received daily injections of apomorphine (2.0 mg/kg SC) for 10 consecutive days to examine the development of sensitization to a direct dopamine agonist. Behavior was monitored on days 1, 5, and 10, using a photobeam system, and on day 10 using the videotape assessments as well. Locomotor sensitization to apomorphine developed in the preweaning vehicle-treated males only. Neither the cocaine-treated males nor any females exhibited locomotor sensitization to repeated apomorphine injections at 2 mg/kg. There were no other treatment-related effects except for grooming, which showed an interaction between treatment and gender. Overall, every behavior analyzed showed significant apomorphine effects, except rearing. Margin time (wall hugging), grooming, and quiet were significantly decreased by apomorphine, while locomotion and the duration of sniffing were increased. In summary, these data indicate that with respect to locomotor activity, the development of sensitization to apomorphine at 2.0 mg/kg is prevented by preweaning cocaine administration in males. These data further suggest that developmental cocaine exposure produces long-term alterations in DA D1 receptor-mediated responses in male rats.
机译：在产后几天（PND）接受可卡因（50 mg / kg SC）治疗的60日龄大鼠，连续10天每天注射阿扑吗啡（2.0 mg / kg SC），以检查对直接致敏作用的发展多巴胺激动剂。使用光电系统在第1、5和10天监控行为，并在第10天使用录像带评估行为。仅在断奶前经媒介物处理的男性中发生了对阿扑吗啡的运动敏化。可卡因治疗的雄性和雌性均未表现出对反复注射2 mg / kg的阿扑吗啡敏感。除美容外，没有其他与治疗相关的作用，这表明治疗与性别之间存在相互作用。总体而言，除饲养外，所有分析的行为均显示了明显的阿扑吗啡作用。阿扑吗啡显着减少了保证时间（围墙拥抱），修饰和安静，而运动和嗅探时间则增加了。总之，这些数据表明，就运动能力而言，通过在男性中断奶可卡因，可以预防对2.0 mg / kg的阿扑吗啡致敏作用的发展。这些数据进一步表明，发育性可卡因暴露会在雄性大鼠中产生DA D1受体介导的反应的长期变化。

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