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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Decreased accumbens dopamine release after cocaine challenge in behaviorally sensitized female rats.
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Decreased accumbens dopamine release after cocaine challenge in behaviorally sensitized female rats.

机译：可卡因攻击后行为敏感的雌性大鼠中伏隔多巴胺释放减少。

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摘要

The effects of the competitive NMDA receptor antagonist CPP on the initiation of behavioral sensitization to acute cocaine and basal and acute cocaine-induced dopamine (DA) release in the nucleus accumbens (NAC) were assessed in female Sprague-Dawley rats. Cocaine pretreated rats (30 mg/kg IP, once daily for 7 days) challenged with cocaine (10 mg/kg) on day 8 displayed increased motor activity relative to controls challenged with cocaine on day 8. This effect was blocked in rats receiving CPP (2 mg/kg) 15 min prior to all cocaine pretreatments. Basal DA levels in the NAC of both cocaine-pretreated and CPP plus cocaine-pretreated rats were higher on day 8 compared to controls. Acute cocaine challenge on day 8 resulted in increased extracellular DA concentrations in the NAC in control rats, no increase in rats pretreated with CPP plus cocaine, and a decrease in rats pretreated with cocaine only. These data demonstrate that development of behavioral sensitization to cocaine in female Sprague-Dawley rats can be completely blocked by a peripherally administered competitive NMDA receptor antagonist and that an increase in DA release in the NAC after a cocaine challenge is not an absolute requirement for expression of motor sensitization to cocaine in female rats.
机译：在雌性Sprague-Dawley大鼠中评估了竞争性NMDA受体拮抗剂CPP对急性可卡因的行为敏化的启动以及基础伏隔核（NAC）中基础和急性可卡因诱导的多巴胺（DA）释放的影响。与在第8天用可卡因攻击的对照组相比，在第8天用可卡因（10 mg / kg）攻击的可卡因预处理的大鼠（30 mg / kg IP，每天一次，连续7天）显示出增加的运动活性。在接受CPP的大鼠中，这种作用被阻断（2 mg / kg）在所有可卡因预处理之前15分钟。与对照组相比，可卡因预处理和CPP加可卡因预处理的大鼠在NAC中的基础DA水平在第8天更高。在第8天，急性可卡因攻击导致对照大鼠NAC中的细胞外DA浓度增加，用CPP加可卡因预处理的大鼠没有增加，而仅用可卡因预处理的大鼠却减少了。这些数据表明，外周给予竞争性NMDA受体拮抗剂可完全阻断雌性Sprague-Dawley大鼠对可卡因的行为致敏性发展，并且可卡因攻击后NAC中DA释放的增加并不是表达NDS的绝对要求。对雌性大鼠的可卡因运动致敏。

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