• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The effects of d-amphetamine on intake of food and a sweet fluid containing cocaine.
【24h】

The effects of d-amphetamine on intake of food and a sweet fluid containing cocaine.

机译：d-苯异丙胺对食物和含有可卡因的甜味液体摄入的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Using a laboratory animal procedure designed to measure two aspects of reinforcement (self-administration and location preference), five adult rhesus monkeys each lived in three chambers: oral cocaine self-administration (0.26 mg/kg/delivery cocaine hydrochloride in a sweet fluid) was specific to one end chamber, food self-administration was specific to the other end chamber, and no food cues or fluid cues were available in the middle chamber. Throughout the 10-h experimental day monkeys experienced multiple food, cocaine, and choice (food vs. sweet cocaine fluid), sessions. Oral d-amphetamine (AMPH; 0.5-1.5 mg/kg) or placebo was administered before the sessions to determine if this anorectic drug would differentially alter food and sweet cocaine fluid self-administration. Further, the effects of AMPH on the length of time a monkey spent in each chamber, when the stimulus cues indicating commodity availability were not present (location preference) were determined. AMPH produced dose-dependent decreases in both food and cocaine self-administration without affecting choice behavior. AMPH also increased the length of time monkeys spent in the food chamber, even when no stimuli indicating food availability were present. These results indicate that the relationship between self-administration and location preference measures of reinforcement is not completely concordant. The current procedure may prove useful in studying these two measures of reinforcement.
机译：使用旨在测量增强作用的两个方面的实验室动物程序（自我给药和位置偏爱），五只成年恒河猴分别生活在三个隔间中：口服可卡因自我给药（0.26 mg / kg /份可卡因甜味液中的可卡因盐酸盐）特定于一个端腔，食物自我管理特定于另一端腔，中间腔中没有食物提示或液体提示。在整个实验的10小时中，猴子经历了多种食物，可卡因和多种选择（食物与甜可卡因液）。术前口服d-苯丙胺（AMPH; 0.5-1.5 mg / kg）或安慰剂，以确定这种厌食药是否会差异性地改变食物和甜可卡因液体的自我给药。此外，当没有表明商品可利用性的刺激提示（位置偏好）时，确定了AMPH对猴子在每个房间中停留的时间长度的影响。 AMPH在食物和可卡因的自我管理中均产生剂量依赖性的降低，而不会影响选择行为。即使没有刺激表明食物的可利用性，AMPH也增加了猴子在食物室中停留的时间。这些结果表明，自我管理与位置偏好增强措施之间的关系并不完全一致。当前的程序可能对研究这两种加固措施很有用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号