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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Feeding and reward interactions from chronic paroxetine treatment.
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Feeding and reward interactions from chronic paroxetine treatment.

机译：长期帕罗西汀治疗的进食和奖励相互作用。

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The self-stimulation paradigm was used to evaluate threshold changes following acute and chronic administration of the selective serotonergic reuptake inhibitor paroxetine; stimulation sites were located in medial forebrain bundle structures. Rats received daily systemic injections of one of three doses of paroxetine (2.5, 5, or 7.5 mg/kg), either with or without stimulation, while the last group received the same number of vehicle injections with stimulation. Frequency thresholds were collected over a period of 6 h on day 1 (acute phase); no marked difference in the values were observed over this time span. Thereafter, the animals were tested every third day (chronic phase), for a total of 11 sessions or roughly 31 days. Commencing around day 10 of the drug treatment, the higher dose of paroxetine produced a significant and persistent facilitation in self-stimulation thresholds, mimicking the delay in clinical response in humans that is well documented. We also monitored on a daily basis the animals' weights and food intake. A large difference in the percent efficiency of food utilization, measured by calculating the ratio of weight change to food intake, was observed between the animals receiving stimulation and those that were not, exclusive to the higher dose of paroxetine. The percent efficiency of food utilization remained low in the animals only receiving the drug treatment, whereas they returned to baseline levels and above in subjects receiving both paroxetine and stimulation. Two findings emerge from these data: 1) the paradigm appears to model the human response to this class of antidepressants, and 2) rewarding stimulation seems to counteract the drug-induced weight loss.
机译：使用自我刺激范例评估急性和慢性给予选择性5-羟色胺再摄取抑制剂帕罗西汀后的阈值变化。刺激部位位于前脑内侧束结构中。大鼠每天全身注射三种剂量的帕罗西汀（2.5、5或7.5 mg / kg），有或无刺激，而最后一组接受相同数量的有刺激的媒介物注射。在第1天（急性期）的6小时内收集频率阈值;在此时间段内未观察到值的显着差异。此后，每三天（慢性期）对动物进行一次测试，总共进行11次或大约31天。从药物治疗的第10天左右开始，较高剂量的帕罗西汀在自我刺激阈值上产生了显着而持久的促进作用，从而模仿了人类临床反应的延迟，这一点已得到充分证明。我们还每天监控动物的体重和食物摄入量。在接受刺激的动物与未接受刺激的动物（高剂量的帕罗西汀除外）之间，观察到通过利用体重变化与食物摄入量的比率来衡量的食物利用效率百分比差异很大。在仅接受药物治疗的动物中，食物利用的效率百分比仍然较低，而在接受帕罗西汀和刺激的受试者中，它们恢复到基线水平或更高。从这些数据中得出两个发现：1）该范例似乎模拟了人类对此类抗抑郁药的反应，以及2）奖励性刺激似乎可以抵消药物引起的体重减轻。

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