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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Stimulus properties of the selective 5-HT reuptake inhibitor fluvoxamine in conditioned taste aversion procedures.
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Stimulus properties of the selective 5-HT reuptake inhibitor fluvoxamine in conditioned taste aversion procedures.

机译：选择性5-HT再摄取抑制剂氟伏沙明在条件性反感规程中的刺激特性。

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摘要

Previous attempts to train pigeons and rats to discriminate between the antidepressant fluvoxamine and its vehicle as assessed in a drug discrimination paradigm have been without success. The present experiments were, therefore, designed to assess in a conditioned taste aversion procedure (CTA) whether or not fluvoxamine possesses stimulus properties. Rats were exposed to a conditioned taste aversion (CTA) procedure. In Experiment I, subjects were given 15 mg/kg fluvoxamine p.o. or vehicle after drinking a novel tasting saccharin solution. In Experiment II, a comparison was made between the effects of 15 mg/kg fluvoxamine i.p., 30 mg/kg fluvoxamine i.p., NaCl, and lithium chloride (LiCl). In Experiment III, subjects were treated with either 10 mg/kg fluoxetine i.p., 30 mg/kg fluvoxamine i.p., or LiCl. CTA was observed after treatment with LiCl, but never after treatment with fluvoxamine or fluoxetine, suggesting that fluvoxamine does not have clear stimulus properties, which can serve as a discriminative stimulus in operant procedures. In a crossfamiliarization CTA procedure in mice, however, fluvoxamine elicited a reliable CTA, suggesting that under certain conditions (species, dose?) selective serotonin reuptake inhibitors (SSRIs) may lead to certain discriminable effects. It is as yet unclear why SSRIs apparently produce such weak and species or situation-dependent discriminable effects.
机译：先前的训练鸽子和大鼠以区别于抗抑郁药氟伏沙明及其媒介物的尝试（在药物辨别范例中评估）一直没有成功。因此，本实验旨在评估条件厌恶规程（CTA）中的氟伏沙明是否具有刺激特性。将大鼠暴露于条件性味觉厌恶（CTA）程序。在实验一中，受试者接受口服氟伏沙明15 mg / kg。或饮用新的品尝糖精溶液的车辆。在实验II中，比较了15mg / kg氟伏沙明腹膜内，30mg / kg氟伏沙明腹膜内，NaCl和氯化锂（LiCl）的作用。在实验III中，受试者接受10 mg / kg氟西汀腹膜内，30 mg / kg氟伏沙明腹膜内或LiCl治疗。在用LiCl处理后观察到CTA，但在用氟伏沙明或氟西汀治疗后未观察到CTA，这表明氟伏沙明没有明确的刺激性，可以在操作程序中用作区分性刺激。但是，在小鼠的交叉熟悉性CTA程序中，氟伏沙明引发了可靠的CTA，这表明在某些条件下（物种，剂量？），选择性5-羟色胺再摄取抑制剂（SSRIs）可能导致某些可识别的作用。尚不清楚为什么SSRI显然会产生如此弱的，与物种或情况有关的可辨别作用。

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