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首页> 外文期刊>Pharmaceutical Biology >Evaluation of free radical scavenging activity of morel mushroom, Morchella esculenta mycelia: A potential source of therapeutically useful antioxidants
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Evaluation of free radical scavenging activity of morel mushroom, Morchella esculenta mycelia: A potential source of therapeutically useful antioxidants

机译：评价羊肚菌，羊肚菌菌丝体的自由基清除活性：治疗有用的抗氧化剂的潜在来源

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摘要

Cellular damage caused by reactive oxygen species (ROS) has been implicated in several diseases and antioxidants are known to protect the body from this damage. Antioxidants thus, have gained significant importance in human health.The search for effective, non-toxic natural compounds with antioxidant activity has intensified in recent years. Mycelia of a number mushrooms have recently been successfully used for the development of novel pharmaceutical products. We examined the aqueous-ethanol extract of cultured mycelia of the morel mushroom, Morchella esculenta (L) Pers. (Morchellaceae) for its ability to scavenge super oxide, hydroxyl, nitric oxide, 2,2'-diphenyl-1-picrylhydrazyl(DPPH), and 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radicals as well as for inhibition of lipid peroxidation. The extract efficiently scavenged all these radicals and also inhibited lipid peroxidation. Ferric reducing antioxidant power (FRAPJ assay indicated the hydrogen donating capacity of the extract. The pulse radiolysis studies using ABTS and carbonate radical (CO_3~) showed that the extract significantly carried out the decay of these radicals in a concentration-dependent manner. In conclusion, the investigation showed that the morel mushroom mycelium is an excellent source of antioxidants which are capable of imparting protection at different levels. The findings suggest the potential therapeutic use of morel mushroom, M. esculenta mycelia as an efficient antioxidant.
机译：由活性氧（ROS）引起的细胞损伤与多种疾病有关，已知抗氧化剂可保护人体免受这种损伤。因此，抗氧化剂在人类健康中已变得非常重要。近年来，人们对具有抗氧化活性的有效，无毒的天然化合物的研究日益加强。最近，许多蘑菇的菌丝体已成功用于开发新型药物产品。我们检查了羊肚菌蘑菇的菌丝体（Morchella esculenta（L）Pers）的乙醇提取物。 （Morchellaceae）具有清除超级氧化物，羟基，一氧化氮，2,2'-二苯基-1-吡啶并肼基（DPPH）和2,2'-叠氮基双（3-乙基苯并噻唑啉-6-磺酸）的能力（ ABTS）自由基以及用于抑制脂质过氧化的自由基。提取物有效清除了所有这些自由基，也抑制了脂质过氧化。还原铁的抗氧化能力（FRAPJ分析表明了提取物的供氢能力），使用ABTS和碳酸盐自由基（CO_3〜）进行的脉冲辐射研究表明，提取物显着地以浓度依赖的方式降解了这些自由基。研究表明，羊肚菌菌丝体是极好的抗氧化剂来源，能够在不同水平上提供保护作用，结果表明，羊肚菌菌，蓝藻菌菌丝体可作为有效的抗氧化剂。

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