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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Acute toluene induces biphasic changes in rat spontaneous locomotor activity which are blocked by remoxipride.
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Acute toluene induces biphasic changes in rat spontaneous locomotor activity which are blocked by remoxipride.

机译：急性甲苯诱导大鼠自发运动活动的双相变化，这被瑞莫昔德所阻止。

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摘要

The behavioral hyperactivity elicited by most drugs of abuse has been linked to changes in mesolimbic dopamine neurotransmission. However, the locomotor stimulant effects of toluene, a constituent in many abused inhalants, has not been clearly associated with this site of action. The present study was designed to examine the hypothesis that toluene-induced hyperactivity is also dependent upon intact dopamine neurotransmission. Using photocell-equipped cages, 600-1200 mg/kg toluene produced an inverted U-shaped dose response. However, in the presence of 5 mg/kg remoxipride, a selective D2-dopamine antagonist toluene-induced hyperactivity was reduced by 57%. The effects of remoxipride appear to be selective as a pretreatment, as it did not reduce either spontaneous locomotor activity or the stimulatory effects of the muscarinic antagonist scopolamine. These results clearly show that toluene induces locomotor hyperactivity through a dopamine-dependent mechanism. Because the mesolimbic dopamine system has been shown to play a role in the rewarding properties of drugs of abuse, its activation by toluene may also underlie the abuse potential of this and other inhalants.
机译：大多数滥用药物引起的行为亢进与中脑边缘多巴胺神经传递的变化有关。但是，甲苯（许多滥用吸入剂中的一种成分）的运动刺激作用尚未明确与此作用部位有关。本研究旨在检查以下假设，即甲苯诱导的多动也取决于完整的多巴胺神经传递。使用装有光电管的笼子，600-1200 mg / kg甲苯产生倒U形剂量反应。但是，在存在5 mg / kg瑞莫必利的情况下，选择性D2-多巴胺拮抗剂甲苯诱导的过度活跃症减少了57％。莫昔普利的作用似乎是一种选择性的预处理，因为它既不降低自发运动能力，也不降低毒蕈碱拮抗剂东pol碱的刺激作用。这些结果清楚地表明，甲苯通过多巴胺依赖性机制诱导运动亢进。由于中脑边缘的多巴胺系统已经显示出在滥用药物的有益特性中起作用，因此甲苯对它的激活也可能是该吸入剂和其他吸入剂潜在滥用的基础。

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