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首页> 外文期刊>Pharmaceutical Biology >Cuminum cyminum extract attenuates scopolamine-induced memory loss and stress-induced urinary biochemical changes in rats: a noninvasive biochemical approach.
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Cuminum cyminum extract attenuates scopolamine-induced memory loss and stress-induced urinary biochemical changes in rats: a noninvasive biochemical approach.

机译：孜然提取物可减轻东pol碱引起的记忆力丧失和应激引起的大鼠尿生化变化：一种非侵入性的生化方法。

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CONTEXT: Cuminum cyminum Linn. (Apiaceae), cumin, is a popular spice with a long history of medicinal use to treat various symptoms such as diarrhea, flatulence, gynecological, and respiratory diseases. OBJECTIVE: To date, no scientific investigation was reported regarding memory-enhancing and antistress activity of cumin fruits. The present study deals with the memory-enhancing and antistress activities and further the antioxidant status via lipid peroxidation inhibition. MATERIALS AND METHODS: Antistress activity was evaluated by inducing stress via forced swimming and the urinary vanillylmandelic acid (VMA) and ascorbic acid were estimated as biomarkers. Memory-enhancing activity was studied by conditioned avoidance response using Cook's pole climbing apparatus in normal and scopolamine-induced amnestic rats. Thiobarbituric acid reactive substances (TBARS) assay was used to evaluate the lipid peroxidation. RESULTS: Daily administration of cumin at doses of 100, 200, and 300 mg/kg body weight 1 h prior to induction of stress inhibited the stress-induced urinary biochemical changes in a dose-dependent manner without altering the levels in normal control groups. The cognition, as determined by the acquisition, retention, and recovery in rats, was observed to be dose-dependent. The extract also produced significant lipid peroxidation inhibition in comparison with known antioxidant ascorbic acid in both rat liver and brain. DISCUSSION AND CONCLUSION: This study provides scientific support for the antistress, antioxidant, and memory-enhancing activities of cumin extract and substantiates that its traditional use as a culinary spice in foods is beneficial and scientific in combating stress and related disorders.
机译：语境：小茴香亚麻。小茴香（小茴香科）是一种受欢迎的香料，具有悠久的药用历史，可用于治疗各种症状，例如腹泻，肠胃气胀，妇科和呼吸系统疾病。目的：迄今为止，尚未有关于小茴香果实增强记忆力和抗应激活性的科学研究的报道。本研究涉及通过脂类过氧化抑制来增强记忆力和抗应激活性，以及​​进一步的抗氧化状态。材料与方法：通过强迫游泳诱导应激来评估抗应激活性，并估计尿香草醛酸（VMA）和抗坏血酸为生物标记。在正常和东碱诱发的记忆删除大鼠中，通过使用Cook的爬杆装置通过条件回避反应研究增强记忆的活动。硫代巴比妥酸反应性物质（TBARS）测定用于评估脂质过氧化作用。结果：在诱导应激前1小时，每天以100、200和300 mg / kg体重的剂量服用孜然，可以剂量依赖性地抑制应激诱导的尿生化变化，而不会改变正常对照组的水平。由大鼠的获取，保留和恢复所确定的认知被观察到是剂量依赖性的。与已知的抗氧化剂抗坏血酸相比，该提取物在大鼠肝脏和大脑中均具有明显的脂质过氧化抑制作用。讨论与结论：这项研究为小茴香提取物的抗应激，抗氧化和增强记忆活性提供了科学依据，并证实了其作为食品中的烹饪香料的传统用途在对抗压力和相关疾病方面是有益且科学的。

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