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Cardioprotective effect of whole fruit extract of pomegranate on doxorubicin-induced toxicity in rat.

机译：石榴全果提取物对阿霉素诱导的大鼠毒性的心脏保护作用。

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CONTEXT: Cardioprotective effects of various plants are generally attributed to their antioxidant activity. The whole fruit extract of pomegranate (WFEP), Punica granatum L. (Punicaceae), has a potent antioxidant activity. Objective: To investigate cardioprotective effect of WFEP against doxorubicin (Dox)-induced cardiotoxicity in rats. MATERIALS AND METHODS: Male Wistar rats were divided randomly into three groups of eight rats each: control (water, 5 mL/kg); Dox (10 mg/kg i.v.) and WFEP (100 mg/kg). Dox was administered in Dox and WFEP groups. After anesthetizing the animals on the last day, electrocardiogram was recorded and blood was analyzed for creatine kinase-MB isoenzyme (CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) activities. Determinations of superoxide dismutase (SOD), reduced glutathione (GSH), lipid peroxidation (LPO) and histopathology of the heart tissues were carried out. RESULTS: The WFEP group showed decreased QT and increase in heart rate (p < 0.05) compared to the Dox group. Significant decrease in CK-MB (p < 0.01), LDH (p < 0.05) and no such significant decrease in AST were observed as compared to the Dox group. There was significant increase in the level of GSH (p < 0.05), whereas inhibition of LPO and increase in SOD concentration was not significant in the WFEP group compared to the Dox group. Histopathological study of the WFEP-treated group showed slight protection against myocardial toxicity induced by Dox. CONCLUSION: Results indicate that WFEP has cardioprotective effect against Dox-induced cardiotoxicity in rats.
机译：背景：各种植物的心脏保护作用通常归因于其抗氧化活性。石榴（WFEP）的整个果实提取物Punica granatum L.（Punicaceae）具有有效的抗氧化活性。目的：探讨WFEP对阿霉素（Dox）诱导的大鼠心脏毒性的保护作用。材料与方法：将雄性Wistar大鼠随机分为三组，每组八只大鼠：对照组（水，5 mL / kg）;对照组（水）。 Dox（静脉注射10 mg / kg）和WFEP（100 mg / kg）。 Dox和WFEP组中均使用Dox。在最后一天麻醉动物后，记录心电图并分析血液中的肌酸激酶-MB同工酶（CK-MB），乳酸脱氢酶（LDH）和天冬氨酸转氨酶（AST）活性。进行了超氧化物歧化酶（SOD），还原型谷胱甘肽（GSH），脂质过氧化（LPO）和心脏组织病理学的测定。结果：与Dox组相比，WFEP组表现出QT降低和心率升高（p <0.05）。与Dox组相比，未观察到CK-MB显着降低（p <0.01），LDH（p <0.05），AST没有显着降低。与Dox组相比，WFEP组的GSH水平显着增加（p <0.05），而LPO的抑制作用和SOD浓度的增加并不显着。 WFEP治疗组的组织病理学研究显示，对Dox诱发的心肌毒性有轻微的保护作用。结论：WFEP对Dox诱导的大鼠心脏毒性具有心脏保护作用。

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