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Antidiabetic Efficacy of Enicostemma littorale Methanol Extract in Alloxan-Induced Diabetic Rats

机译:淡水线虫甲醇提取物对四氧嘧啶致糖尿病大鼠的抗糖尿病作用

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摘要

The glucose lowering and antioxidant effect of a methanol extract of Enicostemma littorale Blume was evaluated in alloxan-induced diabetic rats. Administration of methanol extract (2.5 g/kg body weight/day) to diabetic rats for 20 days reduced blood glucose levels from 466.50 ± 37.07 to 237.20 ± 28.22 (P < 0.01). E. littorale also increased the serum insulin levels of diabetic rats and improved the antioxidant status of diabetic rats. Extract treatment to the diabetic rats significantly increased reduced glutathione levels and decreased erythrocyte catalase activity and lipid peroxida-tion. These results support the use of E. littorale as an antidi-abetic agent by traditional healers in rural pockets of Gujarat.
机译:在四氧嘧啶诱导的糖尿病大鼠中评估了Enicostemma littorale Blume甲醇提取物的降糖和抗氧化作用。给糖尿病大鼠服用甲醇提取物(2.5 g / kg体重/天)20天后,血糖水平从466.50±37.07降低至237.20±28.22(P <0.01)。滨海肠杆菌还增加了糖尿病大鼠的血清胰岛素水平,并改善了糖尿病大鼠的抗氧化状态。糖尿病大鼠的提取物治疗显着增加了降低的谷胱甘肽水平,降低了红细胞过氧化氢酶活性和脂质过氧化作用。这些结果支持传统治疗师在古吉拉特邦农村地区使用滨海肠杆菌作为抗糖尿病药。

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