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Efficacy of Some Plant Extracts in Regulating Corticosteroid-Induced Hyperglycaemia in Mice

机译：某些植物提取物对皮质类固醇诱导的小鼠高血糖的调节作用

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摘要

In an attempt to find the possible regulation of steroid diabetes by plant extracts, relative efficacy of Inula racemosa (root), Gymnema sylvestre (leaf), Boerhaavia diffusa (root) and Ocimum sanctum (leaf) extracts (400, 600, 150 and 500mg/kg. b. wt./day, respectively, for 15 days) in the regulation of dexamethasone-induced hyperglycaemia was studied in mice. Simultaneously, levels.of thyroid hormones (thyroxine and triiodothyronine) were estimated by radio-immunoassay (RIA), to reveal the possible mediation of the effects of the plant extracts through thyroid hormones. While the administration of dexamethasone (1 mg/kg b.wt.) induced hyperglycaemia in mice, at least two plant extracts (out of the four) from Inula racemosa and Gymnema sylvestre, were able to ameliorate the drug induced hyperglycaemia by 24 and 15%, respectively. These effects were comparable to the standard corticosteroid-inhibiting drug, ketoconazole (Keto-Zole~(TM). The lack of increase in hepatic lipid peroxidation and decrease in superoxide dismutase or catalase activity suggest the potential use of these plant extracts in the regulation of corticosteroid-induced hyperglycaemia.
机译：为了找到植物提取物可能对类固醇糖尿病的调节作用，Inula racemosa（根），Gymnema sylvestre（叶），differ Boerhaavia diffusa（根）和Ocimum Sanctum（叶）提取物（400、600、150和500mg）的相对功效在小鼠中研究了地塞米松诱导的高血糖的调节中的每千克体重（kg.b.wt./天，分别持续15天）。同时，通过放射免疫测定法（RIA）估算甲状腺激素（甲状腺素和三碘甲状腺素）的水平，以揭示可能通过甲状腺激素介导植物提取物的作用。地塞米松（1 mg / kg b.wt.）的施用会在小鼠中引起高血糖症，但从Inula racemosa和Gymnema sylvestre中至少有两种植物提取物（四种中的一种）能够在24和15年前缓解药物引起的高血糖症％， 分别。这些效果可与标准的皮质类固醇抑制药物酮康唑（Keto-Zole〜（TM））相媲美。肝脂质过氧化缺乏增加，超氧化物歧化酶或过氧化氢酶活性下降的缺乏表明，这些植物提取物可用于调节肝细胞癌。皮质类固醇诱发的高血糖症。

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