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Cytotoxic and antioxidant properties of selected Scutellaria species from the Western Ghats of Peninsular India

机译：印度半岛西高止山脉精选黄S种类的细胞毒和抗氧化特性

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Context: Scutellaria (Lamiaceae), commonly known as 'Skullcaps', has been extensively used in Traditional Chinese Medicine (TCM). Recently, much emphasis has been given to this genus due to the rich source of bioflavonoids that contribute to its biological properties. Therefore, different species of Scutellaria are being explored worldwide.Objectives: Cytotoxic, antioxidant, and phytochemical properties of Scutellaria colebrookiana Benth and S. violacea (Heyne ex Benth) Don collected (October 2009-February 2010) from Western Ghats of India have been analysed.Materials and methods: In vitro cytotoxicity and free radical scavenging effects of root extracts in various solvents were analysed. Spectrophotometric and HPLC methods were performed for phytochemical analysis.Results: Chloroform extract exhibited significant cytotoxicity in Dalton's Lymphoma Ascites (DLA) and Ehrlich Ascites Carcinoma (EAC) cells with IC_(50) values 150 and 140 mug/mL for S. colebrookiana and 250 and 280 mug/mL for S. violacea, respectively. Moreover, the extract was effective in scavenging free radicals and inhibiting membrane peroxidation in vitro with IC_(50) values 158.3 and 167.5 (superoxide), 17.5 and 28.0 (hydroxyl), 76.25 and 69.75 (DPPH), 24.5 and 28.0 (ABTS), 69.75 and 64.6 (lipid peroxidation), 41 and 31.5 mug/mL (erythrocyte hemolysis), respectively. Antioxidant effect observed with acetone extract was also comparable to that of chloroform extract. Phytochemical screening revealed the presence of baicalein.Discussion and conclusion: Scutellaria species of Western Ghats showed cytotoxic and antioxidant potential and the presence of baicalein. This suggests that S. colebrookiana and 5. violacea could be used as alternative sources for baicalein in view of the reported scarcity of S. baicalensis.
机译：背景：黄cut（唇形科），通常被称为“ Skullcaps”，已在中药（TCM）中广泛使用。最近，由于生物类黄酮的丰富来源对其生物学特性做出了贡献，因此对该类已给予了很大的重视。因此，全世界正在研究不同种类的黄cut。目的：分析了从印度西高止山脉收集的唐cut（2009年10月至2010年2月）的黄S（Scutellaria colebrookiana Benth）和S. violacea（Heyne ex Benth）的细胞毒性，抗氧化剂和植物化学特性。材料与方法：分析了根提取物在各种溶剂中的体外细胞毒性和自由基清除作用。结果：氯仿提取物对道尔顿淋巴瘤腹水（DLA）和艾氏腹水癌（EAC）细胞表现出明显的细胞毒性，其中S. colebrookiana和IC_（50）值分别为150和140 cup / mL和250。紫薇和280毫升/毫升。此外，该提取物可有效清除自由基并在体外抑制膜过氧化，IC_（50）值为158.3和167.5（超氧化物），17.5和28.0（羟基），76.25和69.75（DPPH），24.5和28.0（ABTS），分别为69.75和64.6（脂质过氧化），41和31.5 mug / mL（红细胞溶血）。用丙酮提取物观察到的抗氧化作用也与氯仿提取物相当。植物化学筛选揭示了黄ical素的存在。讨论与结论：西高止山脉的黄cut菌种具有细胞毒性和抗氧化潜能，并且存在黄ical素。这表明鉴于报道的黄ical的缺乏，可将S.colebrookiana和5. violacea用作黄ical素的替代来源。

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