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Hydroalcoholic extract of Urtica circularis: A neuropharmacological profile

机译：荨麻的水醇提取物：神经药理学特征

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Context: The genus Urtica has been known since ancient times. It has known to be useful for the treatment of different human ailments. Objective: The present work evaluated the neuropharmacological effects of a hydroalcoholic extract of Urtica circularis (Hicken) Soraru (Urticaceae). Materials and method: The effect on central nervous system of U. circularis hydroalcoholic extract (from leaves and stems) administered by the intraperitoneal route in mice was evaluated by several tests: Pentobarbital- and midazolam-induced hypnosis, open field, hole board, elevated plus-maze and forced swimming. Phytochemical analysis was performed by high-performance liquid chromatography. Results: A total of 300 trig/kg i.p. of the extract produced a significant prolongation of pentobarbital- (40mg/kg i.p.; 60.1 min versus 25.4 min) and midazolam- (50mg/kg i.v.; 53.4 min versus 25.1 min) induced sleeping time. The extract's administration caused a marked reduction of the head-dipping response (DE_(50): 373 mg/kg i.p.) in the hole-board test. Urtica circularis extract (DE_(50): 46 mg/kg i.p.) reduced the spontaneous locomotor activity in the open field test. Flumazenil and atropine significantly antagonized the extract's effect on the locomotor activity. No motor coordination disturbance was observed in the rota rod test at any doses. In the forced swimming test, the extract did not produce any change in the immobility time and it had no significant effects in elevated plus maze test. The phytochemical analysis revealed the presence of chlorogenic acid, vanillic acid, caffeic acid, vicenin-2, p-cumaric acid, ferulic acid, vitexin and isovitexin. Conclusion: This study revealed that U. circularis hydroalcoholic extract possesses sedative activity, facilitating GABAergic and cholinergic transmission.
机译：背景：荨麻属自古以来就广为人知。众所周知，它可用于治疗各种人类疾病。目的：本工作评估了荨麻（Hitic）苏拉鲁（荨麻科）的水醇提取物的神经药理作用。材料和方法：通过几种试验评估了腹膜内途径对小鼠圆环螺旋藻水醇提取物（来自叶片和茎）的中枢神经系统的影响：戊巴比妥和咪达唑仑引起的催眠作用，视野开阔，孔板，升高加上迷宫和强迫游泳。通过高效液相色谱法进行植物化学分析。结果：总计300 trig / kg i.p.提取物的提取物显着延长了戊巴比妥（40mg / kg i.p.; 60.1分钟对25.4分钟）和咪达唑仑-（50mg / kg i.v.; 53.4分钟对25.1分钟）诱导的睡眠时间。在孔板试验中，提取物的施用导致头浸响应显着降低（DE_（50）：373 mg / kg i.p.）。野荨麻提取物（DE_（50）：46 mg / kg i.p.）在露天试验中降低了自发运动能力。氟马西尼和阿托品显着拮抗提取物对运动活性的影响。在任何剂量的旋转棒试验中均未观察到运动协调障碍。在强制游泳测试中，提取物的固定时间没有变化，并且在高架迷宫测试中没有显着影响。植物化学分析表明，存在绿原酸，香草酸，咖啡酸，Vicenin-2，对枯草酸，阿魏酸，葡萄黄素和异维亭毒素。结论：这项研究表明，圆环螺旋菌水醇提取物具有镇静作用，促进GABA能和胆碱能的传播。

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