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首页> 外文期刊>Pharmacology: International Journal of Experimental and Clinical Pharmacology >Effect of ramipril alone compared to ramipril with eplerenone on diabetic nephropathy in streptozocin-induced diabetic rats.
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Effect of ramipril alone compared to ramipril with eplerenone on diabetic nephropathy in streptozocin-induced diabetic rats.

机译：与雷米普利和依普利农相比，单独使用雷米普利对链脲佐菌素诱导的糖尿病大鼠的糖尿病肾病的影响。

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BACKGROUND/AIMS: We studied the effect of the combined treatment with an angiotensin-converting enzyme (ACE) inhibitor (ramipril) and eplerenone compared with ramipril alone in streptozocin-induced diabetic rats. METHODS: Wistar rats were divided into 4 groups: nondiabetic controls, streptozocin-treated diabetic rats (50 mg/kg), diabetic rats receiving ramipril (1 mg/kg) and diabetic rats treated with the combination of ramipril (1 mg/kg) and eplerenone (100 mg/kg) for 8 weeks. Our model produced early-stage diabetic nephropathy. RESULTS: The diabetic rats developed polyuria, proteinuria, hyperfiltration (assessed by creatinine clearance) and histopathological evidence of renal injury including glomerular hypertrophy and mesangial expansion. Ramipril reduced proteinuria but its combination with eplerenone did not produce any greater benefit. Both treatment approaches prevented glomerular hypertrophy. Addition of eplerenone to ramipril prevented glomerular hyperfiltration. CONCLUSION: Whether eplerenone should be used in addition to an ACE inhibitor or an angiotensin receptor blocker at an early stage of diabetic nephropathy remains questionable.
机译：背景/目的：在链脲佐菌素诱导的糖尿病大鼠中，与单独使用雷米普利相比，我们研究了血管紧张素转换酶（ACE）抑制剂（雷米普利）和依普利酮联合治疗的效果。方法：Wistar大鼠分为4组：非糖尿病对照组，链脲霉素治疗的糖尿病大鼠（50 mg / kg），接受雷米普利（1 mg / kg）治疗的糖尿病大鼠和雷米普利（1 mg / kg）联合治疗的糖尿病大鼠和依普利农（100 mg / kg）持续8周。我们的模型产生了早期糖尿病肾病。结果：糖尿病大鼠出现多尿，蛋白尿，超滤（通过肌酐清除率评估）和肾脏损害的组织病理学证据，包括肾小球肥大和系膜扩张。雷米普利可降低蛋白尿，但将其与依普利农合用不会产生更大的益处。两种治疗方法均可以预防肾小球肥大。雷米普利加依普利农可预防肾小球超滤。结论：在糖尿病性肾病的早期阶段，是否应在血管紧张素转换酶抑制剂或血管紧张素受体阻滞剂的基础上使用依普利农仍然存在疑问。

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