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首页> 外文期刊>Physics in medicine and biology. >Radiation dose enhancement at tissue-tungsten interfaces in HDR brachytherapy
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Radiation dose enhancement at tissue-tungsten interfaces in HDR brachytherapy

机译：HDR近距离放射治疗中组织-钨界面的辐射剂量增加

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HDR BrachyView is a novel in-body dosimetric imaging system for real-time monitoring and verification of the source position in high dose rate (HDR) prostate brachytherapy treatment. It is based on a high-resolution pixelated detector array with a semi-cylindrical multi-pinhole tungsten collimator and is designed to fit inside a compact rectal probe, and is able to resolve the 3D position of the source with a maximum error of 1.5 mm. This paper presents an evaluation of the additional dose that will be delivered to the patient as a result of backscatter radiation from the collimator. Monte Carlo simulations of planar and cylindrical collimators embedded in a tissue-equivalent phantom were performed using Geant4, with an 192Ir source placed at two different source-collimator distances. The planar configuration was replicated experimentally to validate the simulations, with a MOSkin dosimetry probe used to measure dose at three distances from the collimator. For the cylindrical collimator simulation, backscatter dose enhancement was calculated as a function of axial and azimuthal displacement, and dose distribution maps were generated at three distances from the collimator surface. Although significant backscatter dose enhancement was observed for both geometries immediately adjacent to the collimator, simulations and experiments indicate that backscatter dose is negligible at distances beyond 1 mm from the collimator. Since HDR BrachyView is enclosed within a 1 mm thick tissue-equivalent plastic shell, all backscatter radiation resulting from its use will therefore be absorbed before reaching the rectal wall or other tissues. dosimetry, brachytherapy, HDR
机译：HDR BrachyView是一种新颖的体内剂量成像系统，用于实时监测和验证高剂量率（HDR）前列腺近距离放射治疗中的放射源位置。它基于带有半圆柱多针孔钨准直仪的高分辨率像素化检测器阵列，并设计为可安装在紧凑型直肠探头内，并且能够以最大1.5 mm的误差解析源的3D位置。本文介绍了由于准直仪的反向散射辐射而将输送给患者的额外剂量的评估。使用Geant4对嵌入组织等效体模中的平面和圆柱状准直器进行蒙特卡罗模拟，其中192Ir光源放置在两个不同的光源准直器距离处。通过使用MOSkin剂量学探针在距准直仪三个距离处测量剂量的方法，通过实验复制了平面配置以验证模拟效果。对于圆柱状准直器模拟，根据轴向和方位角位移计算反向散射剂量的增加，并在距准直器表面三个距离处生成剂量分布图。尽管在与准直仪紧邻的两个几何结构中均观察到显着的反向散射剂量增加，但是模拟和实验表明，在距准直仪超过1 mm的距离处，反向散射剂量可忽略不计。由于HDR BrachyView封闭在1毫米厚的等同于组织的塑料外壳内，因此，使用它后产生的所有反向散射辐射将在到达直肠壁或其他组织之前被吸收。剂量测定，近距离放射治疗，HDR

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