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首页> 外文期刊>Physics in medicine and biology. >First experimental-based characterization of oxygen ion beam depth dose distributions at the Heidelberg Ion-Beam Therapy Center
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First experimental-based characterization of oxygen ion beam depth dose distributions at the Heidelberg Ion-Beam Therapy Center

机译：海德堡离子束治疗中心首次基于实验的氧离子束深度剂量分布表征

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Over the last decades, the application of proton and heavy-ion beams to external beam radiotherapy has rapidly increased. Due to the favourable lateral and depth dose profile, the superposition of narrow ion pencil beams may enable a highly conformal dose delivery to the tumour, with better sparing of the surrounding healthy tissue in comparison to conventional radiation therapy with photons. To fully exploit the promised clinical advantages of ion beams, an accurate planning of the patient treatments is required. The clinical treatment planning system (TPS) at the Heidelberg Ion-Beam Therapy Center (HIT) is based on a fast performing analytical algorithm for dose calculation, relying, among others, on laterally integrated depth dose distributions (DDDs) simulated with the FLUKA Monte Carlo (MC) code. Important input parameters of these simulations need to be derived from a comparison of the simulated DDDs with measurements. In this work, the first measurements of 16O ion DDDs at HIT are presented with a focus on the determined Bragg peak positions and the understanding of factors influencing the shape of the distributions. The measurements are compared to different simulation approaches aiming to reproduce the acquired data at best. A simplified geometrical model is first used to optimize important input parameters, not known a priori, in the simulations. This method is then compared to a more realistic, but also more time-consuming simulation approach better accounting for the experimental set-up and the measuring process. The results of this work contributed to a pre-clinical oxygen ion beam database, which is currently used by a research TPS for corresponding radio-biological cell experiments. A future extension to a clinical database used by the clinical TPS at HIT is foreseen. As a side effect, the performed investigations showed that the typical water equivalent calibration approach of experimental data acquired with water column systems leads to slight deviations between the experimentally determined and the real Bragg peak positions. For improved accuracy, the energy dependence of the stopping power, and herewith the water equivalent thickness, of the material downstream of the water tank should be considered in the analysis of measured data.
机译：在过去的几十年中，质子束和重离子束在外部束放射治疗中的应用迅速增加。由于有利的横向和深度剂量分布，与传统的光子放射疗法相比，窄离子笔束的叠加可以实现高度保形的剂量递送至肿瘤，并更好地保留周围的健康组织。为了充分利用离子束的预期临床优势，需要对患者治疗进行准确的计划。海德堡离子束治疗中心（HIT）的临床治疗计划系统（TPS）基于快速执行的剂量计算分析算法，除其他外，还依赖于用FLUKA Monte模拟的横向积分深度剂量分布（DDD）卡洛（MC）代码。这些模拟的重要输入参数需要从模拟DDD与测量值的比较中得出。在这项工作中，在HIT上对16O离子DDD的首次测量将重点介绍确定的Bragg峰位置和对影响分布形状的因素的理解。将测量结果与旨在最大程度地重现所采集数据的不同模拟方法进行比较。首先在仿真中使用简化的几何模型来优化重要的输入参数（先验未知）。然后将该方法与更现实，但也更耗时的仿真方法进行比较，可以更好地说明实验设置和测量过程。这项工作的结果有助于建立临床前的氧离子束数据库，研究TPS目前将其用于相应的放射生物学细胞实验。可以预见到HIT的临床TPS使用的临床数据库的未来扩展。副作用是，进行的研究表明，使用水柱系统采集的实验数据的典型水当量校准方法会导致实验确定的布拉格峰位置与实际的布拉格峰位置之间出现微小的偏差。为了提高精度，在分析测量数据时应考虑水箱下游材料的制动力的能量依赖性以及水等效厚度。

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