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首页> 外文期刊>Physics in medicine and biology. >Quantification of T 1ρrelaxation by using rotary echo spin-lock pulses in the presence of B 0inhomogeneity
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Quantification of T 1ρrelaxation by using rotary echo spin-lock pulses in the presence of B 0inhomogeneity

机译：在存在B 0不均匀性的情况下，通过使用旋转回波自旋锁脉冲来量化T1ρ弛豫

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摘要

T 1ρrelaxation is traditionally described as a mono-exponential signal decay with spin-lock time. However, T 1ρquantification by fitting to the mono-exponential model can be substantially compromised in the presence of field inhomogeneities, especially for low spin-lock frequencies. The normal approach to address this issue involves the development of dedicated composite spin-lock pulses for artifact reduction while still using the mono-exponential model for T 1ρfitting. In this work, we propose an alternative approach for improved T 1ρquantification with the widely-used rotary echo spin-lock pulses in the presence of B 0inhomogeneities by fitting to a modified theoretical model which is derived to reveal the dependence of T 1ρ-prepared magnetization on T 1ρ, T 2ρ, spin-lock time, spin-lock frequency and off-resonance, without involving complicated spin-lock pulse design. It has potentials for T 1ρquantification improvement at low spin-lock frequencies. Improved T 1ρmapping was demonstrated on phantom and in vivo rat spin-lock imaging at 3 T compared to the mapping using the mono-exponential model.
机译：传统上，T1ρ松弛被描述为具有自旋锁定时间的单指数信号衰减。但是，在存在场不均匀性的情况下，尤其是对于低自旋锁频率，通过拟合单指数模型进行的T1ρ量化可能会受到很大损害。解决此问题的常规方法包括开发专用的复合自旋锁脉冲以减少伪影，同时仍使用单指数模型进行T1ρ拟合。在这项工作中，我们提出了一种替代方法，该方法通过拟合修改后的理论模型（其揭示了T1ρ制备的磁化强度的依赖性），通过在存在B 0不均匀性的情况下使用广泛使用的旋转回波自旋锁脉冲来改进T1ρ量化。 T1ρ，T2ρ，自旋锁定时间，自旋锁定频率和失谐，无需复杂的自旋锁定脉冲设计。它具有在低自旋锁频率下改善T1ρ量化的潜力。与使用单指数模型进行的映射相比，在幻影和体内大鼠自旋锁成像中以3 T表现出改进的T1ρ映射。

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