...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Physics in medicine and biology. >Quantitative image reconstruction for dual-isotope parathyroid SPECT/CT: Phantom experiments and sample patient studies
【24h】

Quantitative image reconstruction for dual-isotope parathyroid SPECT/CT: Phantom experiments and sample patient studies

机译：双同位素甲状旁腺SPECT / CT的定量图像重建：虚拟实验和样本患者研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We investigated the quantitative accuracy of the model-based dual-isotope single-photon emission computed tomography (DI-SPECT) reconstructions that use Klein-Nishina expressions to estimate the scattered photon contributions to the projection data. Our objective was to examine the ability of the method to recover the absolute activities pertaining to both radiotracers: Tc-99m and I-123. We validated our method through a series of phantom experiments performed using a clinical hybrid SPECT/CT camera (Infinia Hawkeye, GE Healthcare). Different activity ratios and different attenuating media were used in these experiments to create cross-talk effects of varying severity, which can occur in clinical studies. Accurate model-based corrections for scatter and cross-talk with CT attenuation maps allowed for the recovery of the absolute activities from DI-SPECT/CT scans with errors that ranged 0-10% for both radiotracers. The unfavorable activity ratios increased the computational burden but practically did not affect the resulting accuracy. The visual analysis of parathyroid patient data demonstrated that our model-based processing improved adenoma/background contrast and enhanced localization of small or faint adenomas.
机译：我们调查了基于模型的双同位素单光子发射计算机断层扫描（DI-SPECT）重建的定量精度，该重建使用Klein-Nishina表达式来估计散射光子对投影数据的贡献。我们的目标是检验该方法恢复与两种放射性示踪剂Tc-99m和I-123有关的绝对活性的能力。我们通过使用临床混合SPECT / CT相机（Infinia Hawkeye，GE Healthcare）进行的一系列幻像实验验证了我们的方法。在这些实验中，使用了不同的活性比和不同的衰减介质来产生不同严重程度的串扰效应，这在临床研究中可能会发生。基于精确的基于模型的散射和串扰校正，并带有CT衰减图，可从DI-SPECT / CT扫描中恢复绝对活度，两个放射性示踪剂的误差范围均为0-10％。不利的活动比率增加了计算负担，但实际上并没有影响所得的准确性。甲状旁腺患者数据的视觉分析表明，我们基于模型的处理改善了腺瘤/背景对比度并增强了小或微弱腺瘤的定位。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号