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The prediction of output factors for spread-out proton Bragg peak fields in clinical practice.

机译:临床实践中扩展质子布拉格峰场输出因子的预测。

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摘要

The reliable prediction of output factors for spread-out proton Bragg peak (SOBP) fields in clinical practice remained unrealized due to a lack of a consistent theoretical framework and the great number of variables introduced by the mechanical devices necessary for the production of such fields. These limitations necessitated an almost exclusive reliance on manual calibration for individual fields and empirical, ad hoc, models. We recently reported on a theoretical framework for the prediction of output factors for such fields. In this work, we describe the implementation of this framework in our clinical practice. In our practice, we use a treatment delivery nozzle that uses a limited, and constant, set of mechanical devices to produce SOBP fields over the full extent of clinical penetration depths, or ranges, and modulation widths. This use of a limited set of mechanical devices allows us to unfold the physical effects that affect the output factor. We describe these effects and their incorporation into the theoretical framework. We describe the calibration and protocol for SOBP fields, the effects of apertures and range-compensators and the use of output factors in the treatment planning process.
机译:由于缺乏一致的理论框架以及由产生此类场所需的机械装置引入的大量变量,在临床实践中仍无法实现对扩展质子布拉格峰(SOBP)场的输出因子的可靠预测。这些限制使得几乎必须排他性地依赖于各个领域和经验模型的手动校准。我们最近报道了用于预测此类领域的输出因子的理论框架。在这项工作中,我们将在我们的临床实践中描述该框架的实施。在我们的实践中,我们使用治疗输送喷嘴,该喷嘴使用有限且恒定的一组机械设备在整个临床穿透深度或范围和调制宽度范围内产生SOBP场。通过使用一组有限的机械设备,我们可以展现影响输出因子的物理效应。我们描述了这些影响并将其纳入理论框架。我们描述了SOBP场的校准和协议,孔径和距离补偿器的影响以及在治疗计划过程中使用输出因子。

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