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首页> 外文期刊>Pesticide Research Journal >Synthesis and Antifungal Potential of Schiff Bases Derived from Aromatic Aldehydes and 4-Acetylaniline
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Synthesis and Antifungal Potential of Schiff Bases Derived from Aromatic Aldehydes and 4-Acetylaniline

机译：芳香醛和4-乙酰苯胺衍生的席夫碱的合成及抗真菌潜力

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摘要

Condensation of 4-acetylaniline with aromatic aldehydes (I-X) resulted in formation of crude solids (Ia-Xa) that were recrystallized from methanol.The products were characterized as benzal-4-acetylaniline and its C-phenyl derivatives on the basis of elemental analysis and spectral studies and were screened in vitro for antifungal potential against Alternaria alternata, Fusarium oxysporum, Myrothecium roridum and Ustilago tritici by spore germination inhibition technique. 3-Methoxy-4-hydrbxybenzal-4-acetylaniline (VIla) and 3,4,5-trimethoxybenzal-4-acetylaniline (VIa) showed promising potential against F oxysporum with ED_(50) value of 57 and 59 μg mL~(-1), respectively. The most effective compound of the present study was found to be 3-ethoxy-4-hydroxybenzal-4-acetylaniline (VIlla).
机译：4-乙酰基苯胺与芳香醛（IX）的缩合导致形成粗固体（Ia-Xa），然后从甲醇中重结晶。根据元素分析，将产物表征为苯甲醛-4-乙酰基苯胺及其C-苯基衍生物光谱和光谱研究，并通过孢子萌发抑制技术体外筛选了对链格孢菌，尖孢镰刀菌，轮状Myrothecium roridum和Ustilago tritici的抗真菌潜力。 3-甲氧基-4-羟基苯甲醛-4-乙酰基苯胺（VIla）和3,4,5-三甲氧基苯甲醛-4-乙酰基苯胺（VIa）表现出潜在的潜在抗F孢子菌，ED_（50）值为57和59μgmL〜（- 1）。发现本研究中最有效的化合物是3-乙氧基-4-羟基苯并-4-乙酰基苯胺（VIlla）。

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