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Thermodynamics of Multicomponent Liquid Chromatography

机译:多组分液相色谱的热力学

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摘要

Thermodynamic models of multicomponent adsorption in liquid chromatography are summarized and reviewed. A general description of adsorption equilibrium is presented, which is followed by simplified approaches that can be adopted for practical applications. Synergistic and competitive adsorption effects accompanying chromatographic elution are illustrated and methods of their predictions are indicated. The influence of a mobile phase modifier on the retention behavior of chromatographed species is discussed. A manner of mathematical predictions of competitive adsorption of modifiers and solutes is presented. Also in this case the analysis starts with a thermodynamically grounded general description and ends with simplified models suitable for practical purposes of design and optimization of chromatographic separations.
机译:总结了液相色谱中多组分吸附的热力学模型。介绍了吸附平衡的一般描述,然后介绍了可用于实际应用的简化方法。说明了伴随色谱洗脱的协同和竞争性吸附作用,并指出了其预测方法。讨论了流动相改性剂对色谱物质的保留行为的影响。提出了一种数学预测改性剂和溶质竞争性吸附的方式。同样在这种情况下,分析以热力学为基础的一般说明开始,以简化的模型结束,这些简化的模型适用于色谱分离的设计和优化的实际目的。

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