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首页> 外文期刊>Pharmacological reports: PR >Neurochemical and behavioral effects of 8-OH-DPAT following exposure to restraint stress in rats.
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Neurochemical and behavioral effects of 8-OH-DPAT following exposure to restraint stress in rats.

机译：大鼠暴露于约束性应激后8-OH-DPAT的神经化学和行为效应。

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摘要

8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a selective 5-hydroxytryptamine 1A (serotonin; 5-HT(1A)) agonist was used to evaluate the role of somatodendritic and/or postsynaptic 5-HT(1A) receptors following exposure to restraint stress. Exposure to an episode of 2-h restraint stress decreased 24 h cumulative food intake. Intensity of 8-OH-DPAT-induced 5-HT syndrome monitored next day was smaller in restrained than unrestrained animals. Hyperphagic effects of 8-OH-DPAT were comparable in the two groups. Restrained animals injected with saline exhibited an increase in 5-HT levels in the hippocampus, hypothalamus and cortex but not in the midbrain and striatum. 5-Hydroxyindolacetic acid (5-HIAA) increased in the hippocampus, midbrain and cortex but not in the hypothalamus and striatum. 8-OH-DPAT injected at a dose of 0.25 mg/kg decreased 5-HT and 5-HIAA levels in different brain regions of unrestrained as well as restrained animals. The decreases were greater in restrained than unrestrained animals, suggesting a supersensitivity of somatodendritic 5-HT(1A) receptors. The results are discussed in the context of a role of 5-HT(1A) receptor in restraint-induced behavioral deficits.
机译：8-羟基-2-（二-正丙基氨基）四氢化萘（8-OH-DPAT），选择性的5-羟基色胺1A（5-羟色胺; 5-HT（1A））激动剂用于评估体树突状和/或突触后5-HT（1A）受体暴露于约束压力后。暴露于2小时的约束压力发作会减少24小时的累积食物摄入量。受约束的动物第二天监测到的由8-OH-DPAT诱导的5-HT综合征的强度要小于不受约束的动物。在两组中，8-OH-DPAT的高吞噬作用相当。注射盐水的受约束的动物在海马，下丘脑和皮层中的5-HT水平升高，但在中脑和纹状体中没有升高。 5-羟吲哚乙酸（5-HIAA）在海马，中脑和皮质中增加，但在下丘脑和纹状体中没有增加。以0.25 mg / kg的剂量注射的8-OH-DPAT在不受约束的动物和受约束的动物的不同大脑区域中均会降低5-HT和5-HIAA的水平。约束动物的减少幅度大于不受约束的动物，表明躯体树突状5-HT（1A）受体具有超敏性。在限制诱导的行为缺陷中5-HT（1A）受体的作用的上下文中讨论了结果。

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