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首页> 外文期刊>Pharmacological research: The official journal of The Italian Pharmacological Society >Drug therapeutic failures in emergency department patients. A university hospital experience.
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Drug therapeutic failures in emergency department patients. A university hospital experience.

机译：急诊科患者的药物治疗失败。有大学医院的经验。

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Drug therapeutic failure (DTF) could be considered as an adverse drug reaction in which the expected drug effects do not occur following a prescribed pharmacological treatment, including any clinical event that could be related to a low prescribed dose or lack of compliance. DTFs are responsible for increasing disease length, hospitalisation time and social costs, with the worsening of patient quality of life. The aims of the present study are: (1) to estimate the frequency of DTFs among cases of adverse drug events referred to the emergency department; (2) to identify drug classes implicated in DTFs; (3) to analyse the putative causes underlying DTFs. Data presented in this paper were obtained from the Pronto Soccorso and Adverse Drug Events (PSADE) study carried out to analyse drug-related emergency department admissions in several Italian hospitals. Patients, admitted to the emergency department throughout two periods of 10 days each, were interviewed to gain information on their medical status and drug intake during the last two weeks. The present study analysed the patient questionnaires collected in the emergency department of Pisa University Hospital. Among 123 recorded cases of adverse drug event, 41 cases (19:22 male:female ratio; age range: 17-98 years, median age: 75 years) were identified as suspect DTF, resulting in a frequency of 33.33%. A statistical analysis was performed to evaluate the influence of two variables, class of patient age and number of drugs assumed, on DTFs. In accordance with the present findings, showing that the number of drugs assumed by a patient may increase the risk of DTF more than advanced age (odds ratio: 1.371, P<0.02; 1.295, P<0.03, respectively), the prescription of pharmacological combinations might be proposed as a main risk factor for DTF occurrence. In conclusion, our results suggest that DTFs represent an important cause of emergency department admission, particularly in elderly subjects treated with pharmacological associations.
机译：药物治疗失败（DTF）可被视为药物不良反应，其中在处方药治疗后不会发生预期的药物作用，包括可能与处方药剂量低或缺乏依从性有关的任何临床事件。 DTF导致疾病持续时间延长，住院时间和社会成本增加，并且患者的生活质量恶化。本研究的目的是：（1）估计在转交给急诊科的药物不良事件病例中DTF的频率; （2）识别涉及DTF的药物类别; （3）分析潜在DTF的推定原因。本文提供的数据来自Pronto Soccorso和药品不良事件（PSADE）研究，该研究旨在分析意大利几家医院与毒品有关的急诊室的入院情况。在过去两个星期的两个阶段（每次为期10天）中进入急诊室的患者接受了采访，以获取有关其医疗状况和药物摄入量的信息。本研究分析了比萨大学医院急诊科收集的患者问卷。在记录的123例药物不良事件中，有41例（男性与女性的比例为19:22;年龄范围：17-98岁，中位年龄为75岁）被确定为可疑DTF，发生率为33.33％。进行了统计分析，以评估两个变量（患者年龄等级和所用药物数量）对DTF的影响。根据目前的发现，表明患者服用的药物数量可能比老年患者增加DTF的风险（优势比：分别为1.371，P <0.02、1.295，P <0.03），这是药理学处方可能将联合用药作为DTF发生的主要危险因素。总之，我们的结果表明DTF是急诊科入院的重要原因，尤其是在接受药理学协会治疗的老年受试者中。

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