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首页> 外文期刊>Pharmacological research: The official journal of The Italian Pharmacological Society >Effect of elevated intraocular pressure on endothelin-1 in a rat model of glaucoma.
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Effect of elevated intraocular pressure on endothelin-1 in a rat model of glaucoma.

机译：眼内压升高对青光眼大鼠模型内皮素-1的影响。

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摘要

The role of endothelin-1 (ET-1) a potent vasoactive peptide, in glaucoma pathogenesis is receiving increasing attention, particularly in astroglial activation in optic nerve damage. Our laboratory has also shown that ET-1 treatment causes proliferation of cultured human optic nerve head astrocytes to possibly initiate astrogliosis. ET-1 is distributed in retina, optic nerve, and ciliary epithelium, however the effects of elevated intraocular pressure (IOP) (as seen in glaucoma) on ET-1 and ET(B) receptors are not clearly understood. In the present study, the levels of immunoreactive ET-1 (ir-ET-1) in aqueous humour (AH) and optic nerve head (ONH) were determined in the Morrison elevated IOP model of glaucoma. Additionally in the ONH of these rats, immunohistochemical analyses of ET(B) receptors and glial fibrillary acidic protein (GFAP; a marker for astroglial cells and for astrogliosis) were performed. There was 2- to 2.5-fold increase in AH ir-ET-1 levels for rats subjected to elevated IOP, compared to their respective controls. In the Morrison rat model of glaucoma, elevated IOP increased optic nerve ir-ET-1 with concomitant increases in ir-ET(B) and ir-GFAP labelling (possibly indicative of astrogliosis and hypertrophy). As seen in brain astrocytes subjected to neurotrauma, the present findings are suggestive of ET-1's role in astroglial activation, particularly in response to elevated IOP in glaucoma.
机译：内皮素-1（ET-1）是一种有效的血管活性肽，在青光眼发病机理中的作用受到越来越多的关注，尤其是在视神经损伤中的星形胶质细胞活化中。我们的实验室还表明，ET-1处理可导致培养的人视神经头星形胶质细胞增殖，从而可能引发星形胶质细胞增生。 ET-1分布在视网膜，视神经和睫状上皮中，但是尚不清楚眼内压（IOP）升高（如在青光眼中所见）对ET-1和ET（B）受体的影响。在本研究中，在Morrison升高的青光眼IOP模型中测定了房水（AH）和视神经头（ONH）中免疫反应性ET-1（ir-ET-1）的水平。另外，在这些大鼠的ONH中，进行了ET（B）受体和神经胶质原纤维酸性蛋白（GFAP;星形胶质细胞和星形胶质增生的标志物）的免疫组织化学分析。与各自的对照组相比，接受高眼压的大鼠的AH ir-ET-1水平增加了2到2.5倍。在青光眼的Morrison大鼠模型中，IOP升高会增加视神经ir-ET-1，并同时增加ir-ET（B）和ir-GFAP标记（可能表明星形胶质增生和肥大）。正如在遭受神经创伤的脑星形胶质细胞中所见，目前的发现提示ET-1在星形胶质细胞活化中的作用，特别是对青光眼中眼压升高的反应。

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