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首页> 外文期刊>Pharmacological research: The official journal of The Italian Pharmacological Society >Behavioral and developmental outcomes of prenatal and postnatal vanadium exposure in the rat.
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Behavioral and developmental outcomes of prenatal and postnatal vanadium exposure in the rat.

机译：大鼠产前和产后钒暴露的行为和发育结局。

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摘要

The developmental and behavioral outcomes of uninterrupted exposure to vanadium was studied in the rat. Starting 3 days before birth and up to the 100th day of extrauterine life, rats received as drink either a water solution of vanadyl sulphate (300 mg l(-1)containing 70 mg l(-1)of vanadium element, which is equal to an ingested dose of about 10 mg kg(-1)per day of vanadium element) plus NaCl 5 g l(-1), or a water solution of NaCl 5 g l(-1), or plain water [up to weaning (25th day of extrauterine life) treatment was given to dams and offspring]. At weaning, survivors were fewer and body weight was found to be significantly lower in the offspring of vanadium plus NaCl-treated dams than in the offspring of the other two groups. After weaning, growth retardation continued to be significant in both vanadium plus NaCl- and NaCl-treated rats. Such an effect was more pronounced in males than in females. Locomotor activity--evaluated at 1 month of age--was not significantly different in the three groups of rats. In the open-field, male (but not female) vanadium plus NaCl-treated rats had a reduced outer ambulation, rearing posture and grooming activity, and an increased defecation, in comparison with the males of the NaCl group, and reduced rearing in comparison with control males. As concerns ingestive behaviors, the only significant datum was an increased water intake in NaCl-treated males. Finally, at the 100th day of life, working memory was significantly impaired in both vanadium plus NaCl- and NaCl-treated rats. Copyright 2001 Academic Press.
机译：在大鼠中研究了不间断暴露于钒的发育和行为结果。从出生前3天开始直至宫外生活的第100天，大鼠以饮料形式服用硫酸氧钒（300 mg l（-1）的水溶液，其中含有70 mg l（-1）的钒元素，等于每天摄入约10 mg kg（-1）的钒元素）加上NaCl 5 gl（-1）或NaCl 5 gl（-1）的水溶液或纯水[直至断奶（第25天）子宫和后代]。断奶时，钒加NaCl处理的水坝的后代中的幸存者较少，而且体重显着低于其他两组的后代。断奶后，在钒加NaCl处理和NaCl处理的大鼠中，生长迟缓仍然很明显。男性比女性更明显。三组大鼠的运动能力（在1个月大时进行评估）没有显着差异。在野外，与NaCl组的雄性相比，雄性钒（但非雌性）钒加NaCl处理的大鼠的外行走能力，站立姿势和修饰活动减少，排便增加，排便增加。与控制男性。关于摄食行为，唯一重要的数据是NaCl处理的雄性的摄水量增加。最终，在生命的第100天，钒加NaCl和NaCl处理的大鼠的工作记忆均显着受损。版权所有2001学术出版社。

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