...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Physical chemistry chemical physics: PCCP >Solubilization of flurbiprofen within non-ionic Tween 20 surfactant micelles: a ~(19)F and ~1H NMR study
【24h】

Solubilization of flurbiprofen within non-ionic Tween 20 surfactant micelles: a ~(19)F and ~1H NMR study

机译：非离子吐温20表面活性剂胶束中氟比洛芬的增溶：〜（19）F和〜1H NMR研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The solubilization of the poorly water soluble anti-inflammatory drug flurbiprofen in non-ionic Tween 20 surfactant micellar solutions was studied by both ~(19)F and ~1H NMR spectroscopy in an acidic environment. These non-destructive techniques allowed us to investigate the effect of temperature cycling in situ. Using ~(19)F NMR, an increased solubilisation capacity was observed as the temperature increased. This effect became more pronounced above the cloud point, which was reduced by more than 30 °C in the presence of an excess of flurbiprofen. Upon clouding, peak splitting was observed in the ~(19)F spectrum, which indicates that two pools of solubilised flurbiprofen exist that are in slow exchange on the NMR frequency timescale. The clouding and solubilization processes were found to be reversible, albeit with slow kinetics. Based on chemical shift differences of both Tween 20 and flurbiprofen, as well as NOESY experiments, the flurbiprofen was found to be accumulated within the palisade layer of the Tween 20 micelles.
机译：通过〜（19）F和〜1H NMR光谱在酸性环境中研究了水溶性差的消炎药氟比洛芬在非离子Tween 20表面活性剂胶束溶液中的增溶作用。这些无损技术使我们能够就地研究温度循环的影响。使用〜（19）F NMR，观察到随着温度升高，增溶能力增强。在浊点以上，这种作用变得更加明显，在过量的氟比洛芬的存在下，该作用降低了30°C以上。浑浊时，在〜（19）F谱图中观察到峰分裂，这表明存在两个溶解的氟比洛芬池，它们在NMR频率时标上缓慢交换。发现浑浊和溶解过程是可逆的，尽管动力学很慢。根据吐温20和氟比洛芬的化学位移差异以及NOESY实验，发现氟比洛芬在吐温20胶束的栅栏层中积累。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号