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首页> 外文期刊>Physical chemistry chemical physics: PCCP >Vesicle-chloesterol interactions:Effects of added cholesterol on gel-to-liquid crystal transitions in a phospholipid membrane and five dialkyl-based vesicles as monitored using DSC
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Vesicle-chloesterol interactions:Effects of added cholesterol on gel-to-liquid crystal transitions in a phospholipid membrane and five dialkyl-based vesicles as monitored using DSC

机译：囊泡与胆固醇的相互作用：使用DSC监测添加的胆固醇对磷脂膜和5个基于二烷基的囊泡的凝胶-液晶转变的影响

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摘要

Differential scanning calorimetry (DSC) results are reported charactrisign the effects of added cholesterol (CHOL) on vesicle bilayer systems formed in aqueous systems by three sodium dialkylphosphates,(RO)_2PO~-_2-Na~+ where R=dodecyl(DDP),tetradecyl(DTP) and octadecyl(DOP),(ii) two dialkdimethyl-ammonium bromides R_2N~+Me_2Br~-where R=hexadecyl(DHAB0 and octadecyl(DOAB) and (iii) dimyristoylphosphatidylcholine(DMPC).The results are examiend in terms of the effects of added CHOL on the melting temperature T_m and enthalpy change for the gel to liquid crystal transition together with the extent of xo-operative structural changes on meltingas measrued by patch numbers.A key factor is the extent to which added CHOL changes the enthalpies of gel and liquid crystal phases.For DOAB,DDP,DTP and DHAB bilayers added CHOl lowers the enthalpies of both liquid crystal and gel phases,the impact on the liquid-crystal state being mroe dramatic.Added CHOL has no effect on the gel state for DOP but raises the enthalpy of the liquid-crystla state.In the case f DMPC added CHOL increases the enthalpies is more re-organisation than in the absence of CHOL.For all bilayer systems,the effects of CHOL on the enthalpies is more dramatic than the effects on teh melting temperature T_m,pointing to the importance of compensation between enthalpy and entropy hanges on meltig.Tehimpact of aded CHOL can be understood in terms of the relative effects on the enthalpies of liquid crystal and gel states of the bilayers.Also important are the effects of CHOL on patch numbers,the latter indicating the extent of co-operative melting in the bilayers.
机译：报道了差示扫描量热法（DSC）的结果，其特征是添加的胆固醇（CHOL）对由三烷基二烷基磷酸钠（RO）_2PO〜-_2-Na〜+形成的囊泡双层系统的影响，其中R =十二烷基（DDP），十四烷基（DTP）和十八烷基（DOP），（ii）两个二甲基二甲基溴化铵R_2N〜+ Me_2Br〜-，其中R =十六烷基（DHAB0和十八烷基（DOAB），以及（iii）二肉豆蔻酰基磷脂酰胆碱（DMPC）。 CHOL对熔融温度T_m的影响以及凝胶向液晶转变的焓变的影响以及xo-操作性结构变化对融化的程度的影响（通过色斑数量来衡量）。对于DOAB，DDP，DTP和DHAB双层，添加CHOl会降低液晶相和凝胶相的焓，对液晶状态的影响显着。添加CHOL对凝胶无影响DOP的状态，但ra液体晶状体的焓。在添加DMPC的情况下，与没有CHOL的情况相比，增加了CHOL的焓的重组程度更大。对于所有双层系统，CHOL对焓的影响要比其影响大得多。在熔融温度T_m上，指出了焓和熵之间的关系对熔体的补偿很重要。可以从对液晶的焓和双层凝胶态的相对影响方面来理解CHOD的增韧作用。 CHOL对膜片数量的影响，后者表明双层中的合作融化程度。

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