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首页> 外文期刊>Biomaterials >Co-delivery of pEGFP-hTRAIL and paclitaxel to brain glioma mediated by an angiopep-conjugated liposome.
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Co-delivery of pEGFP-hTRAIL and paclitaxel to brain glioma mediated by an angiopep-conjugated liposome.

机译：pEGFP-hTRAIL和紫杉醇向血管胶凝体缀合脂质体介导的脑胶质瘤共递送。

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摘要

In this study, we report an angiopep-2 modified cationic liposome (ANG-CLP) for the efficient co-delivery of a therapeutic gene encoding the human tumour necrosis factor-related apoptosis-inducing ligand (pEGFP-hTRAIL) and paclitaxel (PTX) to glioma. The dual targeting co-delivery system (ANG-CLP/PTX/pEGFP-hTRAIL) improved uptake and gene expression not only in U87 MG cells and BCECs, but also in the glioma bed and infiltrating margin of intracranial U87 MG glioma-bearing models. The system selectively induces apoptosis in U87 MG cells while reducing toxicity to BCECs. The results of the pharmacodynamics studies showed that the apoptosis of glioma cells in in vitro BBB models and in U87 MG glioma-bearing mice induced by ANG-CLP/PTX/pEGFP-hTRAIL was more apparent and widespread than that induced by single medication systems and unmodified co-delivery system. More importantly, the median survival time of brain tumour-bearing mice treated with ANG-CLP/PTX/pEGFP-hTRAIL was 69.5 days, significantly longer than that of other groups, even longer than the commercial temozolomide group (47 days). Therefore, the dual targeting co-delivery system is a promising drug delivery strategy against glioma.
机译：在这项研究中，我们报告了一种血管生成蛋白2修饰的阳离子脂质体（ANG-CLP），用于有效共递送编码人类肿瘤坏死因子相关凋亡诱导配体（pEGFP-hTRAIL）和紫杉醇（PTX）的治疗基因脑胶质瘤。双重靶向共递送系统（ANG-CLP / PTX / pEGFP-hTRAIL）不仅提高了U87 MG细胞和BCEC的摄取和基因表达，而且还改善了颅内U87 MG胶质瘤模型的神经胶质瘤床和浸润边缘。该系统在降低对BCEC的毒性的同时，选择性诱导U87 MG细胞凋亡。药效学研究的结果表明，ANG-CLP / PTX / pEGFP-hTRAIL诱导的体外BBB模型和U87 MG胶质瘤荷瘤小鼠中的神经胶质瘤细胞凋亡比单药系统诱导的更为明显和广泛。未修改的共同投放系统。更重要的是，用ANG-CLP / PTX / pEGFP-hTRAIL处理的荷瘤小鼠的中位生存时间为69.5天，明显长于其他组，甚至比商品替莫唑胺组（47天）还要长。因此，双重靶向共递送系统是针对神经胶质瘤的有前途的药物递送策略。

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