DETERMINATION OF THEOPHYLLINE IN BIOLOGICAL FLUIDS BYISOTOPIC DILUTION MASS SPECTROMETRY

ANDREEA IORDACHE; CORNELIA MESAROS; ONUC COZAR; MONICA CULEAI

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DETERMINATION OF THEOPHYLLINE IN BIOLOGICAL FLUIDS BYISOTOPIC DILUTION MASS SPECTROMETRY

机译：同位素稀释质谱法测定生物流体中的茶碱

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A sensitive analytical method for theophylline determination in biological samples was developed by isotopic dilution mass spectrometry. Quantitative determination of the drug from the resultant tracer spectrum requires deconvolution of the enrichment of the isotopomers. Deconvolution of the ion abundance ratios to yield tracer-to-tracee ratios for each isotopomer was done using Brauman's least squares approach. Comparisons with other other calculation method is presented.

机译：通过同位素稀释质谱法开发了一种用于测定生物样品中茶碱含量的灵敏分析方法。从所得示踪谱图定量确定药物需要对同位素异构体的富集进行反褶积。使用Brauman最小二乘法对每种同位素异构体的离子丰度比进行反卷积以生成示踪物对示踪物的比率。提出了与其他计算方法的比较。

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《Studia Universitatis Babes-Bolyai. Series Physica》 |2009年第2期|共8页
作者
ANDREEA IORDACHE; CORNELIA MESAROS; ONUC COZAR; MONICA CULEAI;
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正文语种 eng
中图分类物理学;
关键词
Drug; biological fluids; isotopic dilution; mass spectrometry; deconvolution;

机译：药物;生物流体;同位素稀释;质谱;解卷积;

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1. DETERMINATION OF THEOPHYLLINE IN BIOLOGICAL FLUIDS BYISOTOPIC DILUTION MASS SPECTROMETRY [J] . ANDREEA IORDACHE, CORNELIA MESAROS, ONUC COZAR, Studia Universitatis Babes-Bolyai. Series Physica . 2009,第2期

机译：同位素稀释质谱法测定生物流体中的茶碱
2. Artifactual Nitration Controlled Measurement of Protein-Bound 3-Nitro-L-tyrosine in Biological Fluids and Tissues by Isotope Dilution Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry. [J] . Stadler RH Chemical research in toxicology . 2002,第10期

机译：同位素稀释液相色谱电喷雾电离串联质谱法对生物流体和组织中蛋白质结合的3-硝基-L-酪氨酸进行人工硝化控制。
3. Determination of Am and Cm in spent nuclear fuels by isotope dilution inductively coupled plasma mass spectrometry and isotope dilution thermal ionization mass spectrometry after separation by high-performance liquid chromatography [J] . Frederic Chartier, Michel Aubert, Mireille Pilier Fresenius' Journal of Analytical Chemistry . 1999,第4期

机译：高效液相色谱法分离同位素稀释电感耦合等离子体质谱和同位素稀释热电离质谱法测定乏核燃料中的Am和Cm
4. Targeted Metabolomic Analysis of Nucleosides in biological fluids by Isotope Dilution Liquid Chromatography electrospray ionization tandem Mass Spectrometry [C] . Jaeman Byun, Anna V. Mathew, Subramaniam Pennathur American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：同位素稀释液相色谱电喷雾电离串联质谱法对生物液中核苷的靶向核苷分析
5. Part I. Supercritical fluid extraction and liquid chromatography-electrospray mass spectrometry of selected drugs of abuse from various biological matrices. Part II. HPLC determination of selected drugs using smallbore and nonporous octadecylsilane columns. [D] . Spell, Jade Christopher. 1998

机译：第一部分：从各种生物基质中选择的滥用药物的超临界流体萃取和液相色谱-电喷雾质谱法。第二部分使用小口径和无孔十八烷基硅烷色谱柱进行HPLC测定所选药物。
6. The quantitative analysis of 6-keto PGF1 alpha in biological fluids by stable isotope dilution utilizing gas chromatography-mass spectrometry (GC-MS) proceedings [O] . P. Barnes, C. T. Dollery, C. N. Hensby 1980

机译：稳定同位素稀释-气相色谱-质谱法（GC-MS）对生物液体中6-酮PGF1α的定量分析会议结果
7. Determination of trace level iodine in biological and botanical reference materials by isotope dilution mass spectrometry [O] . J.W. Gramlich, T.J. Murphy 1989

机译：同位素稀释质谱法测定生物和植物参考材料中痕量碘
8. Determination of Regenerated Sarin (GB) in Minipig and Human Blood by Gas Chromatography-Chemical Ionization Mass Chemical Ionization Mass Spectrometry Using Isotope Dilution and Large Volume Injection [R] . Jakubowski, E. M. , McGuire, J. M. , Evans, R. A. , 2005

机译：用同位素稀释和大体积进样气相色谱 - 化学电离质谱联用化学电离法测定小型猪和人血中的再生沙林（GB）

DETERMINATION OF THEOPHYLLINE IN BIOLOGICAL FLUIDS BYISOTOPIC DILUTION MASS SPECTROMETRY

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