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Holism and Life Manifestations: Molecular and Space-Time Biology

机译：整体论与生命表现：分子与时空生物学

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Appeals of philosophers to look for new concepts in sciences arebeing met with a weak response. Limited attention is paid to therelation between synthetic and analytic approach in solvingproblems of biology. An attempt is presented to open adiscussion on a possible role of holism. The term "lifemanifestations" is used in accordance with phenomenology.Multicellular creatures maintain milieu interieur to keep anaqueous milieu intracellulair in order to transform the energy ofnutrients into the form utilizable for driving cellular lifemanifestations. Milieu interieur enables to integrate this kind ofmanifestations into life manifestations of the whole multicellularcreatures. The integration depends on a uniqueness anduniformity of the genome of cells, on their mutual recognitionand adherence. The processes of ontogenetic developmentrepresent the natural mode of integration of cellular lifemanifestations. Functional systems of multicellular creatures arebeing established by organization of integrable cells using a widerange of developmental processes. Starting from the zygotedivision the new being displays all properties of a whole creature,although its life manifestations vary. Therefore, the wholeorganism is not only more than its parts, as supposed by holism,but also more than developmental stages of its lifemanifestations. Implicitly, the units of whole multicellularcreature are rather molecular and developmental events than thecells per se. Holism, taking in mind the existence of molecularand space-time biology, could become a guide in looking for anew mode of the combination of analytical and syntheticreasoning in biology.
机译：哲学家寻求科学新概念的呼吁反应微弱。在解决生物学问题时，对合成方法和分析方法之间的关系给予了有限的关注。有人试图就整体主义的可能作用展开讨论。根据现象学，使用术语“生命表现”。多细胞生物维持环境间环境，保持含水环境内纤维素，以将营养物的能量转化为可用于驱动细胞生命表现的形式。 Milieu interieur可以将这种表现形式整合到整个多细胞生物的生命表现中。整合取决于细胞基因组的唯一性和统一性，取决于它们的相互识别和粘附。个体发育的过程代表细胞生命表现整合的自然模式。多细胞生物的功能系统是通过使用各种各样的发育过程来组织可整合细胞而建立的。从受精卵开始，新生物显示整个生物的所有属性，尽管其生命表现各不相同。因此，整个有机不仅是整体主义所认为的部分，而且还不仅仅是其生命表现的发展阶段。隐含地，整个多细胞生物的单位实际上是分子和发育事件，而不是细胞本身。考虑到分子生物学和时空生物学的存在，整体论可以成为寻找生物学中分析和合成推理结合的新模式的指南。

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